Hierarchically structured core–shell nanofibrous membrane for one‐step blood separation and liver biomarkers detection

IF 4.4 3区工程技术 Q2 ENGINEERING, CHEMICAL

AIChE Journal Pub Date : 2026-09-24 DOI:10.1002/aic.70654

Jianjing Shen, Min Zhou, Mengjiao Zhu, Xueli Yuan, Shuo Xue, Wei Zhang, Yu Liu, Tao Liu, Guangru Zhang, Zhenyu Chu

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引用次数: 0

Abstract

Chronic liver disease (CLD) affects over 844 million people and causes more than 2 million deaths annually worldwide. Current blood tests, though convenient and low‐cost, require plasma separation using bulky instruments with lengthy turnaround times. Herein, we have proposed a permeation‐biosensing membrane integrating membrane separation with electrochemical biosensor for on‐site quantification of lactate and alpha‐fetoprotein (AFP). This membrane is one‐step weaved by core‐shell nanofibers through potential‐regulated electrospinning. Its top side is featured by a biocompatible porous structure to effectively reject blood cells to allow plasma permeation. The bottom side immobilized the bio‐recognizer (enzyme or antibody) to capture liver biomarkers (lactate or AFP). Using finger‐prick blood from clinical patients, the membrane achieves total analysis times of 140 s for lactate and 22 min for AFP, including the blood separation and analysis periods. This facile and onsite whole‐blood‐test membrane enables a portable device for home‐in daily monitoring of long‐term liver disease.

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用于一步血液分离和肝脏生物标志物检测的分层结构核-壳纳米纤维膜

慢性肝病每年影响全球8.44亿人，造成200多万人死亡。目前的血液检测虽然方便且成本低，但需要使用体积庞大的仪器进行血浆分离，周转时间长。在此，我们提出了一种将膜分离与电化学生物传感器相结合的渗透生物传感膜，用于乳酸和α -胎蛋白（AFP）的现场定量。这种膜是由核壳纳米纤维通过电位调节的静电纺丝一步编织而成的。它的顶部具有生物相容性多孔结构，可以有效地排斥血细胞，使血浆渗透。底部固定化生物识别器（酶或抗体）以捕获肝脏生物标志物（乳酸或AFP）。使用临床患者的手指刺血，该膜对乳酸的总分析时间为140秒，对AFP的总分析时间为22分钟，包括血液分离和分析时间。这种简便的现场全血测试膜使便携式设备能够用于长期肝脏疾病的家庭日常监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AIChE Journal 工程技术-工程：化工

CiteScore

7.10

自引率

10.80%

发文量

411

审稿时长

3.6 months

期刊介绍： The AIChE Journal is the premier research monthly in chemical engineering and related fields. This peer-reviewed and broad-based journal reports on the most important and latest technological advances in core areas of chemical engineering as well as in other relevant engineering disciplines. To keep abreast with the progressive outlook of the profession, the Journal has been expanding the scope of its editorial contents to include such fast developing areas as biotechnology, electrochemical engineering, and environmental engineering. The AIChE Journal is indeed the global communications vehicle for the world-renowned researchers to exchange top-notch research findings with one another. Subscribing to the AIChE Journal is like having immediate access to nine topical journals in the field. Articles are categorized according to the following topical areas: Biomolecular Engineering, Bioengineering, Biochemicals, Biofuels, and Food Inorganic Materials: Synthesis and Processing Particle Technology and Fluidization Process Systems Engineering Reaction Engineering, Kinetics and Catalysis Separations: Materials, Devices and Processes Soft Materials: Synthesis, Processing and Products Thermodynamics and Molecular-Scale Phenomena Transport Phenomena and Fluid Mechanics.