Glucuronyl Glucosyloleanolate: A Safe and Potent AI-Discovered Depigmenting Saponin

IF 3.5 4区医学 Q2 DERMATOLOGY

Journal of Cosmetic Dermatology Pub Date : 2026-09-23 DOI:10.1111/jocd.71210

Yannick Quesnel, Michael Gold

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引用次数: 0

Abstract

Purpose

Saponins are amphiphilic glycosides found in plants. They have long been used in traditional Asian remedies for their anti-inflammatory, protective, and rejuvenating properties. One representative, Glucuronyl Glucosyloleanolate (GGO), was recently discovered using a combination of artificial intelligence and experimental testing as a depigmenting agent. Its safety has been verified in humans during a patch test on 12 volunteers, followed by an HRIPT study on 100 volunteers. Finally, its depigmenting efficacy has been demonstrated after a clinical trial on 60 volunteers.

Methods

A 48-h patch test was conducted on 12 volunteers using the pure compound.
HRIPT: a patch with 0.1% GGO in mineral oil was applied to 100 volunteers repeatedly over 3 weeks. After a 2-week rest, a single patch was applied again to the induction site and to a new, untreated site for the challenge phase.
Clinical trial: monocentric blind study of GGO (0.01% weight) versus placebo on a multi-ethnic panel with pigmentation spots.

Results

Safety: No skin irritation or adverse effects were observed in the patch test assay confirming the product's excellent safety. On the 100 volunteers, during the induction period, no reaction of irritation was observed after 3 weeks and during the challenge phase, no allergic reaction was observed. Based on these results, GGO demonstrated very good skin compatibility and does not show a sensitizing effect.
Efficacy: all subgroups showed significant depigmentation from Day 21 onwards, which continued to increase in a similar manner to that observed with localized depigmentation. After 84 days, the level of depigmentation achieved was 10% on Asian, 14% on Caucasian and North African skin, and 24% on black skin. Dark Pigmentation spots on Asian and Caucasian skin depigmented at a rate 34% faster than the overall skin tone, resulting in their visual fading

Conclusion

Glucuronyl Glucosyloleanolate, identified through AI-enhanced biopharma strategies, shows strong skin-brightening efficacy and safety. It depigments dark spots faster than skin tone brightening in an 84-day clinical trial. Non-irritant and potent at low doses, it promises broad cosmetic and medical applications (melasma). Future investigations should assess its anti-aging and antioxidative potential to broaden its scope of application.

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葡萄糖醛酸葡萄糖齐墩酸酯：一种安全有效的人工智能发现的脱色皂素

目的皂苷是存在于植物中的两亲性糖苷。长期以来，它们一直被用于传统的亚洲疗法中，因为它们具有抗炎、保护和恢复活力的特性。其中一种代表，葡萄糖醛酸葡萄糖齐墩酸酯（GGO），最近被发现使用人工智能和实验测试相结合的方法作为脱色剂。在对12名志愿者进行的斑贴试验中，它的安全性得到了人体的验证，随后又对100名志愿者进行了HRIPT研究。最后，通过60名志愿者的临床试验，证明了其脱色效果。方法对12名志愿者进行48 h斑贴试验。HRIPT：在矿物油中添加0.1% GGO的贴片，在3周内反复应用于100名志愿者。休息2周后，在诱导部位和未处理的新部位再次应用单个贴片。临床试验：GGO（0.01%重量）与安慰剂在有色素沉着斑的多种族小组中的单中心盲研究。结果安全性：在斑贴试验中未观察到皮肤刺激或不良反应，证实了产品的极好安全性。100名志愿者，诱导期3周后未见刺激反应，激发期未见过敏反应。基于这些结果，GGO显示出非常好的皮肤相容性，并且没有显示出致敏作用。疗效：从第21天开始，所有亚组都显示出明显的色素沉着，并且以与局部色素沉着相似的方式继续增加。84天后，亚洲皮肤脱色率为10%，高加索和北非皮肤为14%，黑色皮肤为24%。亚洲人和高加索人皮肤上的深色色素沉着斑的脱色速度比整体肤色快34%，导致其视觉褪色。结论通过人工智能增强生物制药策略鉴定的葡糖醛酸葡萄糖齐墩酸酯具有较强的美白功效和安全性。在一项为期84天的临床试验中，它去除黑斑的速度比美白肤色的速度快。无刺激性和低剂量有效，它承诺广泛的美容和医疗应用（黄褐斑）。未来的研究应评估其抗衰老和抗氧化潜力，以扩大其应用范围。

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来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.