Risk Factors for Implant Failure and Peri‐Implantitis: A Retrospective Cohort Study

IF 5.9 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research Pub Date : 2026-09-26 DOI:10.1111/clr.70181

Nathalia Vilela, Bruno C. V. Gurgel, Hélio D. P. da Silva, Claudio M. Pannuti, Poliana M. Duarte

{"title":"Risk Factors for Implant Failure and Peri‐Implantitis: A Retrospective Cohort Study","authors":"Nathalia Vilela, Bruno C. V. Gurgel, Hélio D. P. da Silva, Claudio M. Pannuti, Poliana M. Duarte","doi":"10.1111/clr.70181","DOIUrl":null,"url":null,"abstract":"Objectives This retrospective cohort study evaluated patient‐, implant‐, site‐, procedural‐, biological‐, and prosthesis/mechanics‐related factors associated with early and late implant failure and peri‐implantitis. Material and Methods Electronic health record data from a university center were analyzed. Forty patient‐, implant/site‐, biologic‐, and prosthesis‐related variables were evaluated in relation to early failure, late failure, and peri‐implantitis. Bivariate and survival analyses were performed, followed by mixed‐effects regression models appropriate to each outcome. Robustness was assessed via clustered bootstrap resampling, penalized regression, and sensitivity analyses. Results A total of 264 patients and 554 implants were assessed. Cumulative implant failure was 6.8% (3.4% early; 3.4% late), and peri‐implantitis incidence was 7.6%. In multivariable analyses, self‐reported penicillin allergy (OR = 7.9; 95% CI: 2.7–23.7) and anterior implant location (OR = 5.4; 95% CI: 2.0–14.0) were associated with higher odds of early implant failure, whereas antihypertensive medication use (OR = 0.26; 95% CI:0.08–0.91) was associated with lower odds ( p < 0.05). Late implant failure was associated with hypertension (HR = 2.1; 95% CI: 1.3–3.3), previously grafted sites (HR = 1.4; 95% CI:1.0–1.9), and bone‐level implants (HR = 10.4; 95% CI: 5.5–19.5). In cluster‐robust sensitivity analysis, the association between bone‐level implants and late implant failure was attenuated but remained significant (HR = 3.38; 95% CI: 1.96–5.84). Peri‐implantitis was associated with periodontitis (HR = 3.6; 95% CI: 1.89–6.97), excess cement (HR = 2.7; 95% CI: 1.25–5.88), and PLCBL (HR = 2.1; 95% CI: 1.09–4.13) ( p < 0.05). Robustness analyses generally supported the direction of the identified associations, although some effect estimates were attenuated. Conclusions Implant failure and peri‐implantitis are associated with distinct, potentially modifiable patient‐ and treatment‐related factors. Recognition of these factors may help identify patients and implants at increased risk of adverse outcomes.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"51 1","pages":""},"PeriodicalIF":5.9000,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Oral Implants Research","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1111/clr.70181","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives This retrospective cohort study evaluated patient‐, implant‐, site‐, procedural‐, biological‐, and prosthesis/mechanics‐related factors associated with early and late implant failure and peri‐implantitis. Material and Methods Electronic health record data from a university center were analyzed. Forty patient‐, implant/site‐, biologic‐, and prosthesis‐related variables were evaluated in relation to early failure, late failure, and peri‐implantitis. Bivariate and survival analyses were performed, followed by mixed‐effects regression models appropriate to each outcome. Robustness was assessed via clustered bootstrap resampling, penalized regression, and sensitivity analyses. Results A total of 264 patients and 554 implants were assessed. Cumulative implant failure was 6.8% (3.4% early; 3.4% late), and peri‐implantitis incidence was 7.6%. In multivariable analyses, self‐reported penicillin allergy (OR = 7.9; 95% CI: 2.7–23.7) and anterior implant location (OR = 5.4; 95% CI: 2.0–14.0) were associated with higher odds of early implant failure, whereas antihypertensive medication use (OR = 0.26; 95% CI:0.08–0.91) was associated with lower odds ( p < 0.05). Late implant failure was associated with hypertension (HR = 2.1; 95% CI: 1.3–3.3), previously grafted sites (HR = 1.4; 95% CI:1.0–1.9), and bone‐level implants (HR = 10.4; 95% CI: 5.5–19.5). In cluster‐robust sensitivity analysis, the association between bone‐level implants and late implant failure was attenuated but remained significant (HR = 3.38; 95% CI: 1.96–5.84). Peri‐implantitis was associated with periodontitis (HR = 3.6; 95% CI: 1.89–6.97), excess cement (HR = 2.7; 95% CI: 1.25–5.88), and PLCBL (HR = 2.1; 95% CI: 1.09–4.13) ( p < 0.05). Robustness analyses generally supported the direction of the identified associations, although some effect estimates were attenuated. Conclusions Implant failure and peri‐implantitis are associated with distinct, potentially modifiable patient‐ and treatment‐related factors. Recognition of these factors may help identify patients and implants at increased risk of adverse outcomes.

查看原文本刊更多论文

种植体失败和种植体周围炎的危险因素：一项回顾性队列研究

本回顾性队列研究评估了患者、种植体、部位、程序、生物学和假体/力学相关因素与早期和晚期种植体失败和种植体周围炎的关系。材料与方法对某大学中心电子病历资料进行分析。40个患者、种植体/部位、生物学和假体相关变量被评估为早期失败、晚期失败和种植体周围炎的相关因素。进行双变量和生存分析，然后采用适合每个结果的混合效应回归模型。鲁棒性通过聚类自举重采样、惩罚回归和敏感性分析进行评估。结果共评估264例患者和554颗种植体。累积种植体失败为6.8%（早期3.4%，晚期3.4%），种植体周围炎发生率为7.6%。在多变量分析中，自我报告的青霉素过敏（OR = 7.9; 95% CI: 2.7-23.7）和种植体前侧位置（OR = 5.4; 95% CI: 2.0-14.0）与早期种植体失败的几率较高相关，而抗高血压药物使用（OR = 0.26; 95% CI: 0.08-0.91）与早期种植体失败的几率较低相关（p < 0.05）。晚期种植体失败与高血压（HR = 2.1; 95% CI: 1.3-3.3）、先前移植部位（HR = 1.4; 95% CI: 1.0-1.9）和骨水平种植体（HR = 10.4; 95% CI: 5.5-19.5）相关。在聚类鲁棒性敏感性分析中，骨水平种植体与晚期种植体失败之间的关联减弱，但仍然显著（HR = 3.38; 95% CI: 1.96-5.84）。种植体周围炎与牙周炎（HR = 3.6; 95% CI: 1.89-6.97）、骨水泥过量（HR = 2.7; 95% CI: 1.25-5.88）和PLCBL （HR = 2.1; 95% CI: 1.09-4.13）相关（p < 0.05）。稳健性分析总体上支持确定关联的方向，尽管一些效应估计被减弱。结论：种植体失败和种植体周围炎与不同的、潜在可改变的患者和治疗相关因素相关。识别这些因素可能有助于识别不良后果风险增加的患者和植入物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Oral Implants Research 医学-工程：生物医学

CiteScore

7.70

自引率

11.60%

发文量

149

审稿时长

3 months

期刊介绍： Clinical Oral Implants Research conveys scientific progress in the field of implant dentistry and its related areas to clinicians, teachers and researchers concerned with the application of this information for the benefit of patients in need of oral implants. The journal addresses itself to clinicians, general practitioners, periodontists, oral and maxillofacial surgeons and prosthodontists, as well as to teachers, academicians and scholars involved in the education of professionals and in the scientific promotion of the field of implant dentistry.