Assessing the impact of mixed exposure to 18 PFASs on dyslipidemia risk: An epidemiological study in middle-aged and elderly adults

IF 4.6 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2026-10-01 Epub Date: 2026-09-24 DOI:10.1016/j.etap.2026.105175

Chiqun Shan, Xinhui Qiu, Qinru Xiao, Yiming Ge, Bo Fu, Yuli Lin, Aihua Guo, Mengyan Li, Pan Xu, Jimin Xu, Shaoyou Lu, Haobo Chen

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引用次数: 0

Abstract

Dyslipidemia is a major cardiovascular risk factor, and per- and polyfluoroalkyl substances (PFASs) may disrupt lipid metabolism. This cross-sectional study measured urinary concentrations of 18 PFASs and fasting serum lipids in 214 middle-aged and elderly adults from Guangzhou, China. Associations were assessed using regression models and three mixture approaches: weighted quantile sum regression, quantile g-computation, and Bayesian kernel machine regression, with stratification by sex and age. Twelve PFASs were detected in over 60% of participants, with PFBA and PFPeA showing the highest concentrations. Short-chain PFASs, including PFBA, PFHxA, and PFBS, were positively associated with total cholesterol, triglycerides, and low-density lipoprotein, whereas PFHpA showed inverse associations. 6:2-Cl-PFESA was associated with lower high-density lipoprotein and total cholesterol. Mixture analyses showed no overall association but suggested antagonistic and interactive effects. Associations were stronger in men and adults aged 60–75 years. Prospective studies are needed to clarify causality and mechanisms.

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.