Extracerebral microvascular burden links to dementia risk and brain structural changes: Evidence from a large-scale cohort study.

IF 4.4 Q1 CLINICAL NEUROLOGY

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-09-23 eCollection Date: 2026-07-01 DOI:10.1002/dad2.70489

Jialin Li, Yingzhe Wang, Chunyu Yin, Mei Cui, Jincheng Li, Chen Suo, Kelin Xu, Zhenqiu Liu, Li Jin, Xingdong Chen, Yanfeng Jiang

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引用次数: 0

Abstract

Introduction: The contribution of extracerebral microvascular disease (MVD) burden to dementia risk remains unclear.

Methods: Among 484,896 UK Biobank participants (median follow-up 8.5 years), baseline extracerebral MVD (retinopathy, nephropathy, peripheral neuropathy) and incident dementia were identified via hospital records. Aging-related brain changes were evaluated using magnetic resonance imaging (MRI) -derived volumes and white matter integrity.

Results: MVD was 2.6 times more prevalent among participants who developed dementia than dementia-free individuals (8.0% vs 3.1%) and ranked second among vascular comorbidities after coronary artery disease. Each additional MVD burden was associated with a higher dementia risk, comparable to coronary artery disease (hazard ratio = 1.69 vs. 1.72). Earlier onset conferred stronger risk, and coexisting vascular diseases further amplified associations (p-trend < 0.001). MVD burden was also associated with global brain atrophy and reduced white matter integrity.

Discussion: Extracerebral MVD burden is associated with dementia risks and brain imaging changes, supporting integrated vascular risk stratification and management for dementia.

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来源期刊

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Medicine-Psychiatry and Mental Health

CiteScore

7.80

自引率

7.50%

发文量

101

审稿时长

8 weeks

期刊介绍： Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.