Intergenerational and individual effects of smoking exposure on non-alcoholic fatty liver disease: A Mendelian randomization study.

IF 2.4 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Tobacco Induced Diseases Pub Date : 2026-09-24 eCollection Date: 2026-01-01 DOI:10.18332/tid/226690

Siqi Xie, Lan Liu, Bing Zhang, Jinna Zhang

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引用次数: 0

Abstract

Introduction: Tobacco exposure has been linked to an increased risk of non-alcoholic fatty liver disease (NAFLD) in observational studies, yet evidence remains unclear due to confounding factors and reverse effect. This study aimed to explore the potential associations of maternal smoking around birth and age of smoking initiation with NAFLD risk.

Methods: Genome-wide association data for maternal smoking around birth, age of smoking initiation, and NAFLD were sourced from large-scale Genome-Wide Association Studies (GWAS) datasets. Qualified single nucleotide polymorphisms (SNPs) associated with the two exposures served as instrumental variables in two-sample Mendelian randomization analyses, which utilized the inverse-variance weighted (IVW) method, weighted median estimator, and MR-Egger regression to explore their potential associations with NAFLD. Sensitivity analyses confirmed no obvious directional pleiotropy, while significant heterogeneity was detected among included SNPs.

Results: Genetically predicted maternal smoking significantly elevated NAFLD susceptibility (IVW: OR=1.98; 95% CI: 1.16-3.39), validated by weighted median. No definitive link was found between smoking initiation age and NAFLD. No evidence supported a potential effect of NAFLD on maternal smoking around birth in reverse MR.

Conclusions: This study supports a potential association between maternal smoking around birth and NAFLD, while smoking initiation age lacks sufficient genetic evidence.

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吸烟暴露对非酒精性脂肪肝的代际和个体影响：一项孟德尔随机研究

在观察性研究中，烟草暴露与非酒精性脂肪性肝病（NAFLD）风险增加有关，但由于混杂因素和反向效应，证据尚不清楚。本研究旨在探讨母亲出生前后吸烟和开始吸烟年龄与NAFLD风险的潜在关联。方法：来自大规模全基因组关联研究（GWAS）数据集的孕产妇出生前后吸烟、开始吸烟年龄和NAFLD的全基因组关联数据。在两样本孟德尔随机化分析中，与两次暴露相关的合格单核苷酸多态性（snp）作为工具变量，该分析利用反方差加权（IVW）方法、加权中位数估计和MR-Egger回归来探索它们与NAFLD的潜在关联。敏感性分析证实没有明显的方向性多效性，而纳入的snp之间存在显著的异质性。结果：通过加权中位数验证，遗传预测的母亲吸烟显著提高NAFLD易感性（IVW: OR=1.98; 95% CI: 1.16-3.39）。没有发现吸烟年龄与NAFLD之间的明确联系。结论：本研究支持产妇出生前后吸烟与NAFLD之间的潜在关联，而开始吸烟的年龄缺乏足够的遗传证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tobacco Induced Diseases SUBSTANCE ABUSE-PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

CiteScore

5.30

自引率

5.40%

发文量

审稿时长

12 weeks

期刊介绍： Tobacco Induced Diseases encompasses all aspects of research related to the prevention and control of tobacco use at a global level. Preventing diseases attributable to tobacco is only one aspect of the journal, whose overall scope is to provide a forum for the publication of research articles that can contribute to reducing the burden of tobacco induced diseases globally. To address this epidemic we believe that there must be an avenue for the publication of research/policy activities on tobacco control initiatives that may be very important at a regional and national level. This approach provides a very important "hands on" service to the tobacco control community at a global scale - as common problems have common solutions. Hence, we see ourselves as "connectors" within this global community. The journal hence encourages the submission of articles from all medical, biological and psychosocial disciplines, ranging from medical and dental clinicians, through health professionals to basic biomedical and clinical scientists.