Cembrane- and Casbane-Type Diterpenes from the South China Sea Soft Coral Sinularia nanolobata.

IF 5.7 2区医学 Q1 CHEMISTRY, MEDICINAL

Marine Drugs Pub Date : 2026-09-10 DOI:10.3390/md24090317

Yao Dong, Xiao Xiao, Li-Gong Yao, Lin-Fu Liang, Song-Wei Li, Yue-Wei Guo

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Abstract

Five new cembrane-type diterpenes (1-5), one new casbane-type diterpene (7), and ten known related ones (6, 8-16) were isolated from the South China Sea soft coral Sinularia nanolobata. The structures of new compounds were elucidated through comprehensive spectroscopic analysis, NMR calculation with DP4+ probability analysis, time-dependent density functional theory-electronic circular dichroism (TDDFT-ECD) calculations, and comparison with the reported spectroscopic data of known analogs. Structurally, compounds 2-5 featured rare five- to seven-membered oxygen-containing heterocyclic rings with diverse joints, reflecting remarkable chemical diversity of secondary metabolites. In bioassays, all isolates were evaluated for their cytotoxic and anti-inflammatory effects. Although no significant cytotoxic or anti-inflammatory activity was observed, the structural novelty of these compounds expands the chemical diversity of this class of natural products, providing valuable leads for further structural modifications and biological investigations.

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南海软珊瑚中膜型和卡斯宾型二萜。

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来源期刊

Marine Drugs 医学-医药化学

CiteScore

9.60

自引率

14.80%

发文量

671

审稿时长

1 months

期刊介绍： Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.