Dietary vitamin C intake and the risk of islet autoimmunity and type 1 diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY) Study.

IF 4.5 2区医学 Q2 NUTRITION & DIETETICS

European Journal of Nutrition Pub Date : 2026-09-24 DOI:10.1007/s00394-026-04116-2

Markus Mattila, Lazarus K Mramba, Sari Niinistö, Iris Erlund, Xiang Liu, Ulla Uusitalo, Carin Andrén Aronsson, Sandra Hummel, Brigitte I Frohnert, Hemang M Parikh, Stephen S Rich, William Hagopian, Jorma Toppari, Åke Lernmark, Anette G Ziegler, Marian Rewers, Jeffrey P Krischer, Leena Hakola, Jill M Norris, Suvi M Virtanen

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引用次数: 0

Abstract

Purpose: We explored the associations between vitamin C intake and the risk of islet autoimmunity (IA) and/or type 1 diabetes in genetically at-risk children. Furthermore, we explored associations between vitamin C metabolism-related single nucleotide polymorphisms (SNPs) and type 1 diabetes outcomes.

Methods: The current study within Environmental Determinants of Diabetes in the Young (TEDDY) cohort included 8478 children followed up every 3-6 months for relevant autoantibodies and diet. Dietary vitamin C intake was assessed longitudinally throughout childhood using age-specific dietary assessment methods and analysed using repeated measurements. Cox regression was used for the primary analyses and Bayesian joint longitudinal-survival models as sensitivity analyses.

Results: A total of 777 (9.2%) children developed IA, including 292 (3.4%) with IAA-first and 337 (4.0%) with GADA-first autoimmunity; 319 (41.0%) progressed to type 1 diabetes. Mean (SD) vitamin C intake was 60.7 (38.8) mg/1000 kcal. Higher vitamin C intake was associated with an increased risk of IAA-first autoimmunity (adjusted hazard ratio 1.04; 95% confidence interval 1.00-1.07, per 10 mg/1000 kcal increase) while lowest and highest tertiles of intake were associated with increased risk of GADA-first autoimmunity as compared to mid-tertile [(1.65; 1.20-2.27) and (1.42; 1.02-1.98), respectively]. Sensitivity analyses using Bayesian joint longitudinal-survival models supported the primary findings and suggested nonlinear associations between vitamin C intake and the risks of IA and multiple IA. Associations between vitamin C-related SNPs and study outcomes did not withstand correction for multiple testing.

Conclusion: Vitamin C intake was not consistently associated with IA or progression to type 1 diabetes. However, the observed nonlinear association, with lowest risk for moderate intakes, merits further investigation.

Trial registration: NCT00279318, 06/09/2004.

查看原文本刊更多论文

膳食维生素C摄入与胰岛自身免疫和1型糖尿病的风险：青少年糖尿病的环境决定因素（TEDDY）研究

目的：我们探讨维生素C摄入与遗传风险儿童胰岛自身免疫（IA）和/或1型糖尿病风险之间的关系。此外，我们探索了维生素C代谢相关的单核苷酸多态性（snp）与1型糖尿病结局之间的关系。方法：目前在青少年糖尿病环境决定因素（TEDDY）队列中进行的研究包括8478名儿童，每3-6个月随访一次相关自身抗体和饮食。在整个儿童时期，使用特定年龄的饮食评估方法对膳食维生素C摄入量进行纵向评估，并使用重复测量进行分析。初步分析采用Cox回归，敏感性分析采用贝叶斯联合纵向生存模型。结果：共有777例（9.2%）患儿发生IA，其中IAA-first自身免疫292例（3.4%），GADA-first自身免疫337例（4.0%）；319例（41.0%）进展为1型糖尿病。维生素C的平均（SD）摄入量为60.7 (38.8)mg/1000 kcal.较高的维生素C摄入量与IAA-first自身免疫的风险增加相关（校正风险比为1.04；95%可信区间为1.00-1.07，每增加10 mg/1000 kcal），而与中等三分位数相比，最低和最高三分位数的摄入量与GADA-first自身免疫的风险增加相关[分别为（1.65;1.20-2.27）和（1.42;1.02-1.98）]。使用贝叶斯联合纵向生存模型的敏感性分析支持了初步发现，并表明维生素C摄入量与IA和多发性IA风险之间存在非线性关联。维生素c相关snp与研究结果之间的关联无法经受多重检验的校正。结论：维生素C摄入与IA或进展为1型糖尿病并不一致相关。然而，观察到的非线性关联，与最低的风险适度摄入，值得进一步调查。试验注册：NCT00279318, 06/09/2004。

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来源期刊

European Journal of Nutrition 医学-营养学

CiteScore

10.20

自引率

2.00%

发文量

295

审稿时长

6 months

期刊介绍： The European Journal of Nutrition publishes original papers, reviews, and short communications in the nutritional sciences. The manuscripts submitted to the European Journal of Nutrition should have their major focus on the impact of nutrients and non-nutrients on immunology and inflammation, gene expression, metabolism, chronic diseases, or carcinogenesis, or a major focus on epidemiology, including intervention studies with healthy subjects and with patients, biofunctionality of food and food components, or the impact of diet on the environment.