Beyond insulin resistance: insights into the clinical utility of TyG and TG/HDL-C in hospitalized patients.

IF 2.5

Hormones (Athens, Greece) Pub Date : 2026-09-23 DOI:10.1007/s42000-026-00830-y

Rafailia Gidari, Marina Ioannidou, Iraklis Leonidis, Djordje S Popovic, Theocharis Koufakis

{"title":"Beyond insulin resistance: insights into the clinical utility of TyG and TG/HDL-C in hospitalized patients.","authors":"Rafailia Gidari, Marina Ioannidou, Iraklis Leonidis, Djordje S Popovic, Theocharis Koufakis","doi":"10.1007/s42000-026-00830-y","DOIUrl":null,"url":null,"abstract":"Background: The triglyceride-glucose (TyG) index and triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio are established surrogate markers of insulin resistance and cardiometabolic risk, but their interpretation in hospitalized patients remains unclear.Methods: In this cross-sectional study, we evaluated associations of TyG and TG/HDL-C with clinical characteristics, laboratory parameters, and cause of admission in 101 consecutive internal medicine inpatients.Results: Both indices correlated strongly with triglycerides (TyG: ρ = 0.765, p < 0.001; TG/HDL-C: ρ = 0.861, p < 0.001) and were associated with renal dysfunction (urea: TyG ρ = 0.391, p < 0.001; TG/HDL-C ρ = 0.300, p = 0.002). Urea remained independently associated with TyG (β = 0.003, p = 0.033) and TG/HDL-C (β = 0.006, p = 0.003). Hematological (β=-0.815, p = 0.007) and infectious/fever of unknown origin admissions (β=-0.663, p = 0.039) were independently associated with lower TyG values.Conclusions: In hospitalized patients, TyG and TG/HDL-C reflect a broader cardiometabolic-inflammatory-renal profile, warranting cautious interpretation and further study.","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hormones (Athens, Greece)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s42000-026-00830-y","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The triglyceride-glucose (TyG) index and triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio are established surrogate markers of insulin resistance and cardiometabolic risk, but their interpretation in hospitalized patients remains unclear.

Methods: In this cross-sectional study, we evaluated associations of TyG and TG/HDL-C with clinical characteristics, laboratory parameters, and cause of admission in 101 consecutive internal medicine inpatients.

Results: Both indices correlated strongly with triglycerides (TyG: ρ = 0.765, p < 0.001; TG/HDL-C: ρ = 0.861, p < 0.001) and were associated with renal dysfunction (urea: TyG ρ = 0.391, p < 0.001; TG/HDL-C ρ = 0.300, p = 0.002). Urea remained independently associated with TyG (β = 0.003, p = 0.033) and TG/HDL-C (β = 0.006, p = 0.003). Hematological (β=-0.815, p = 0.007) and infectious/fever of unknown origin admissions (β=-0.663, p = 0.039) were independently associated with lower TyG values.

Conclusions: In hospitalized patients, TyG and TG/HDL-C reflect a broader cardiometabolic-inflammatory-renal profile, warranting cautious interpretation and further study.

查看原文本刊更多论文

胰岛素抵抗之外：TyG和TG/HDL-C在住院患者中的临床应用

背景：甘油三酯-葡萄糖（TyG）指数和甘油三酯-高密度脂蛋白胆固醇（TG/HDL-C）比值是胰岛素抵抗和心脏代谢风险的替代指标，但它们在住院患者中的解释尚不清楚。方法：在本横断面研究中，我们评估了101例连续内科住院患者的TyG和TG/HDL-C与临床特征、实验室参数和入院原因的关系。结果：这两个指标都与甘油三酯密切相关（TyG: ρ = 0.765, p）。结论：在住院患者中，TyG和TG/HDL-C反映了更广泛的心脏代谢-炎症-肾脏特征，需要谨慎解释和进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Hormones (Athens, Greece)

自引率

0.00%

发文量