Long-Term Trajectories of Multidimensional Outcomes in Psychosis Following Early Intervention During the Critical Period: The PEPP-Montreal 10+ Study Protocol

IF 2.3 4区医学 Q3 PSYCHIATRY

Early Intervention in Psychiatry Pub Date : 2026-09-23 DOI:10.1111/eip.70258

Olivier Percie du Sert, Joseph Ghanem, Vanessa McGrory, Karyne Anselmo, Kelly K. Anderson, Srividya Iyer, Ridha Joober, Jai Shah, Ashok Malla, Martin Lepage

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引用次数: 0

Abstract

Introduction

While early intervention services (EIS) have demonstrated short-term benefits, the long-term maintenance of these gains remains uncertain. Individuals with first-episode psychosis exhibit significant variability in their course of recovery. Understanding the risk and protective factors that shape long-term outcome trajectories is essential to predicting and promoting sustained recovery. Here, we present the protocol for an extended 10-year follow-up study of social, mental, cognitive, and physical health outcomes, supplemented through linkage with health administrative databases to offer a holistic perspective on long-term outcome trajectories.

Aim

The primary objective of the study is to model the heterogeneity of long-term trajectories across multiple outcome dimensions over a 10-year follow-up period using data-driven methods.

Method

The Prevention and Early Intervention Program for Psychoses (PEPP-Montreal) is a well-established, high-fidelity EIS program operating within a universal healthcare system and an epidemiologically defined catchment area in South-West Montréal, Canada. Between 2003 and 2018, PEPP-Montreal conducted a detailed two-year longitudinal assessment of 689 individuals aged 14–35 with first-episode affective or non-affective psychosis.

Discussion

This study will help distinguish clinically meaningful subgroups, characterize their profiles, and identify early predictors of long-term outcomes while providing insight into the mechanisms of change within trajectories. In particular, the study will assess whether trajectories shaped during the critical period are sustained over the long term. To our knowledge, this represents the most comprehensive investigation of long-term trajectories following EIS in North America and is expected to lay the groundwork for optimizing EIS and developing personalized interventions.

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关键时期早期干预后精神病多维结局的长期轨迹：PEPP-Montreal 10+研究方案

虽然早期干预服务（EIS）已显示出短期效益，但这些收益的长期维持仍不确定。首发精神病患者在康复过程中表现出显著的可变性。了解影响长期结果轨迹的风险和保护因素对于预测和促进持续复苏至关重要。在这里，我们提出了一项延长的10年随访研究方案，包括社会、心理、认知和身体健康结果，并通过与卫生管理数据库的联系进行补充，以提供长期结果轨迹的整体视角。目的：本研究的主要目的是利用数据驱动的方法对10年随访期间多个结果维度的长期轨迹的异质性进行建模。方法：精神病预防和早期干预项目（pep - montreal）是一个完善的、高保真的EIS项目，在加拿大西南montracal的全民医疗保健系统和流行病学定义的集水区内运行。2003年至2018年期间，PEPP-Montreal对689名14-35岁的首发情感性或非情感性精神病患者进行了为期两年的详细纵向评估。讨论：这项研究将有助于区分临床有意义的亚组，描述他们的特征，并确定长期结果的早期预测因素，同时提供对轨迹变化机制的洞察。特别是，该研究将评估在关键时期形成的轨迹是否会长期持续。据我们所知，这代表了北美地区对EIS长期轨迹最全面的调查，并有望为优化EIS和开发个性化干预措施奠定基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Early Intervention in Psychiatry 医学-精神病学

CiteScore

4.80

自引率

5.00%

发文量

112

审稿时长

6-12 weeks

期刊介绍： Early Intervention in Psychiatry publishes original research articles and reviews dealing with the early recognition, diagnosis and treatment across the full range of mental and substance use disorders, as well as the underlying epidemiological, biological, psychological and social mechanisms that influence the onset and early course of these disorders. The journal provides comprehensive coverage of early intervention for the full range of psychiatric disorders and mental health problems, including schizophrenia and other psychoses, mood and anxiety disorders, substance use disorders, eating disorders and personality disorders. Papers in any of the following fields are considered: diagnostic issues, psychopathology, clinical epidemiology, biological mechanisms, treatments and other forms of intervention, clinical trials, health services and economic research and mental health policy. Special features are also published, including hypotheses, controversies and snapshots of innovative service models.