A compact sequence-defined repetitive peptide for topical ocular plasmid DNA delivery.

IF 6.1 3区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

Biomaterials Science Pub Date : 2026-09-24 DOI:10.1039/d6bm00916f

Hasitieer Bahetibieke, Yansong Zhang, Xia Zhang, Jiawen Ye, Lu Wang, Sicheng Tang, Xingjie Zan, Hao Chen

引用次数: 0

Abstract

A compact sequence-defined repetitive peptide, (CYR)₃, was designed for ocular plasmid DNA delivery. Integrating cationic, aromatic, and cysteine residues (CYR)₃ condenses plasmids into near-neutral biocompatible nanoparticles, achieving efficient intracellular transport, functional anti-angiogenic therapy in vitro, and preliminary in vivo topical corneal transfection.

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一种紧凑的序列定义的重复肽，用于局部眼部质粒DNA递送。

设计了一种紧凑的序列定义的重复肽（CYR）3，用于眼部质粒DNA传递。整合阳离子、芳香和半胱氨酸残基（CYR）3将质粒浓缩成接近中性的生物相容性纳米颗粒，在体外实现高效的细胞内运输、功能性抗血管生成治疗和初步的体内局部角膜转染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomaterials Science MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

11.50

自引率

4.50%

发文量

556

期刊介绍： Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions.