Integrating nutritional biomarkers into precision nutrition research and practice

IF 0.3 Q4 NUTRITION & DIETETICS

CAHIERS DE NUTRITION ET DE DIETETIQUE Pub Date : 2026-08-01 Epub Date: 2026-09-24 DOI:10.1016/j.cnd.2026.08.009

Ana Laura de la Garza

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Abstract

Background

Precision nutrition seeks to optimize dietary recommendations by integrating biological, clinical, and environmental determinants of individual variability. Nutritional biomarkers have emerged as essential tools to characterize dietary exposure, metabolic responses, and disease risk.

Methods

This invited lecture synthesized evidence from human, clinical, and experimental studies examining the application of nutritional biomarkers in precision nutrition. Findings from fatty acid profiles from phospholipid (PL) and cholesterol ester (CE) fractions, gut microbiome, nutrigenetics, and ongoing multi-omics analyses were integrated to illustrate current applications and future directions.

Results

The evidence demonstrated that circulating fatty acid profiles, particularly within serum phospholipids and cholesteryl esters, objectively reflected dietary patterns and were associated with systemic inflammation, and metabolic risk. Experimental studies further showed that dietary modulation of the gut microbiota altered lipid metabolism, endotoxemia, inflammatory pathways, and host metabolic responses, highlighting the central role of microbiota-derived metabolites as emerging nutritional biomarkers. In addition, nutrigenetic evidence indicated that genetic variability contributes to heterogeneous responses to dietary interventions, supporting the incorporation of polygenic information into personalized nutrition strategies. Finally, ongoing analyses from the oriGen cohort illustrated how integrating nutritional biomarkers with anthropometric, clinical, and lifestyle data enables the characterization of distinct cardiometabolic and obesity phenotypes, providing a more comprehensive framework for predicting disease risk and therapeutic response.

Conclusions

Nutritional biomarkers have evolved from complementary research tools to central components of precision nutrition. Their integration with multi-omics technologies and advanced analytical approaches, including artificial intelligence, provides unprecedented opportunities to improve dietary assessment, identify biologically meaningful metabolic phenotypes, predict individual responses to nutrition interventions, and facilitate the translation of precision nutrition into clinical practice. Future research should focus on validating integrated biomarker panels that support evidence-based, individualized dietary recommendations for the prevention and management of chronic metabolic diseases.

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将营养生物标志物融入精准营养研究与实践

背景：精准营养旨在通过整合个体差异的生物学、临床和环境决定因素来优化饮食建议。营养生物标志物已成为表征饮食暴露、代谢反应和疾病风险的重要工具。精准营养旨在通过整合个体差异的生物学、临床和环境决定因素来优化饮食建议。营养生物标志物已成为表征饮食暴露、代谢反应和疾病风险的重要工具。方法本讲座综合了人体、临床和实验研究的证据，探讨了营养生物标志物在精确营养中的应用。来自磷脂（PL）和胆固醇酯（CE）组分的脂肪酸谱、肠道微生物组、营养遗传学和正在进行的多组学分析的发现被整合在一起，以说明当前的应用和未来的方向。本次特邀讲座综合了来自人类、临床和实验研究的证据，研究了营养生物标志物在精确营养中的应用。来自磷脂（PL）和胆固醇酯（CE）组分的脂肪酸谱、肠道微生物组、营养遗传学和正在进行的多组学分析的发现被整合在一起，以说明当前的应用和未来的方向。结果有证据表明，循环脂肪酸谱，特别是血清磷脂和胆固醇酯，客观地反映了饮食模式，并与全身性炎症和代谢风险相关。实验研究进一步表明，肠道微生物群的饮食调节改变了脂质代谢、内毒素血症、炎症途径和宿主代谢反应，突出了微生物群衍生代谢物作为新兴营养生物标志物的核心作用。此外，营养遗传学证据表明，遗传变异有助于对饮食干预的异质反应，支持将多基因信息纳入个性化营养策略。最后，来自oriGen队列的持续分析表明，如何将营养生物标志物与人体测量学、临床和生活方式数据相结合，能够表征不同的心脏代谢和肥胖表型，为预测疾病风险和治疗反应提供更全面的框架。有证据表明，循环脂肪酸谱，特别是血清磷脂和胆固醇酯中的脂肪酸谱，客观地反映了饮食模式，并与全身炎症和代谢风险有关。实验研究进一步表明，肠道微生物群的饮食调节改变了脂质代谢、内毒素血症、炎症途径和宿主代谢反应，突出了微生物群衍生代谢物作为新兴营养生物标志物的核心作用。此外，营养遗传学证据表明，遗传变异有助于对饮食干预的异质反应，支持将多基因信息纳入个性化营养策略。最后，来自oriGen队列的持续分析表明，如何将营养生物标志物与人体测量学、临床和生活方式数据相结合，能够表征不同的心脏代谢和肥胖表型，为预测疾病风险和治疗反应提供更全面的框架。结论营养生物标志物已从辅助研究工具发展成为精准营养的核心组成部分。它们与多组学技术和先进的分析方法（包括人工智能）相结合，为改善饮食评估、识别生物学上有意义的代谢表型、预测个体对营养干预的反应，以及促进精准营养转化为临床实践提供了前所未有的机会。未来的研究应侧重于验证综合生物标志物，以支持基于证据的个性化饮食建议，以预防和管理慢性代谢性疾病。营养生物标志物已经从互补的研究工具发展成为精确营养的核心组成部分。它们与多组学技术和先进的分析方法（包括人工智能）相结合，为改善饮食评估、识别生物学上有意义的代谢表型、预测个体对营养干预的反应，以及促进精准营养转化为临床实践提供了前所未有的机会。未来的研究应侧重于验证综合生物标志物，以支持基于证据的个性化饮食建议，以预防和管理慢性代谢性疾病。

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来源期刊

CAHIERS DE NUTRITION ET DE DIETETIQUE NUTRITION & DIETETICS-

CiteScore

0.60

自引率

33.30%

发文量

审稿时长

65 days

期刊介绍： Les Cahiers de nutrition et de diététique sont le lieu de communication reconnu pour les médecins spécialistes de la nutrition, les diététiciens, les professionnels et les chercheurs de agro-alimentaire, les enseignants et les étudiants. Les Cahiers de nutrition et de diététique abordent les sujets se rapportant à la biologie générale, à la médecine et à la nutrition, aux aliments, aux comportements alimentaires, à la diététique pratique, ainsi que des thèmes variés : activité physique, apports nutritionnels conseillés, dénutrition, alcool, obésité de enfant, aliments à effet santé, plaisir alimentaire, restauration collective, goûters et collations, allergies alimentaires...