Association of ADRB2 polymorphisms with maternal adiposity indicators in Brazilian postpartum women: Preliminary results

IF 0.3 Q4 NUTRITION & DIETETICS

CAHIERS DE NUTRITION ET DE DIETETIQUE Pub Date : 2026-08-01 Epub Date: 2026-09-24 DOI:10.1016/j.cnd.2026.08.062

Clara Lima Cardoso, Ana Sophia Lacerda, Ana Clara Fonseca, Maria Luiza Azeredo Britto, Luiza Barreto Fonseca, Manuela Barreto, Giovana Andriole, Maira Coppola Auler, José Guilherme de Santana Santos, Felipe Rabelo Costa, Katherine Bittencourt, Karina dos Santos

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Abstract

Objective

To evaluate the association of the ADRB2 rs1042713 and rs1042714 polymorphisms with maternal adiposity indicators, including pre-pregnancy body mass index (BMI), current BMI, gestational weight gain (GWG), and postpartum weight retention (PPWR).

Methods

A cross-sectional study was carried out at a University Hospital in Rio de Janeiro, Brazil, from March 2024 to May 2025. Participants were adult postpartum women (=20 years old) between 6 weeks and 12 months after delivery. Pre-pregnancy weight was obtained from the maternal pregnancy booklet and/or self-reported during a structured interview. Current weight and height were obtained through anthropometric assessment. Pre-pregnancy and current BMI were classified according to World Health Organization criteria. GWG was calculated as the difference between pre-pregnancy weight and the final weight of pregnancy, while PPWR was calculated as the difference between current and pre-pregnancy weight. Genomic DNA was extracted from saliva samples, and ADRB2 rs1042713 (G/A) and rs1042714 (C/G) polymorphisms were genotyped using TaqMan real-time polymerase chain reaction assays. Associations were tested under dominant models using the Mann-Whitney U test (P < 0.05). The study was approved by the institutional Ethics Committee (CAAE 70713423.8.0000.5258; approval number 6.273.645).

Results

A total of 196 and 74 women were evaluated for the rs1042713 and rs1042714 polymorphism, respectively. The median age was 29 years (IQR: 25–34). Women carrying the AG/AA genotype for the rs1042713 polymorphism, showed lower current BMI values [27.99 vs. 29.93 kg/m²; P = 0.048] and lower pre-pregnancy BMI values [27.02 vs. 29.71 kg/m²; P = 0.029] compared with those carrying the GG genotypes. No significant differences were observed between groups regarding GWG [12.0 vs. 10.0 kg; P > 0.05] or PPWR [5.0 vs. 6.0 kg; P > 0.05]. For the rs1042714 polymorphism, no significant differences were identified between genotype groups for all the evaluated variables (P > 0.05).

Conclusions

The ADRB2 rs1042713 polymorphism was associated with maternal adiposity, as reflected by pre-pregnancy and current BMI, but not GWG and PPWR. Conversely, no significant association was identified between rs1042714 and the adiposity-related outcomes assessed.

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ADRB2多态性与巴西产后妇女产妇肥胖指标的关联：初步结果

目的探讨ADRB2 rs1042713和rs1042714基因多态性与孕妇孕前体重指数（BMI）、当前体重指数（BMI）、妊娠体重增加（GWG）和产后体重保持（PPWR）等肥胖指标的关系。评估ADRB2 rs1042713和rs1042714多态性与孕妇孕前体重指数（BMI）、当前BMI、妊娠期体重增加（GWG）和产后体重保持（PPWR）等肥胖指标的关系。方法于2024年3月至2025年5月在巴西里约热内卢某大学医院进行横断面研究。参与者为产后6周到12个月的成年产后妇女（=20岁）。孕前体重从孕妇怀孕手册和/或在结构化访谈中自我报告。目前的体重和身高通过人体测量评估获得。根据世界卫生组织的标准对孕前和目前的BMI进行分类。GWG计算为妊娠前体重与最终妊娠体重之差，PPWR计算为当前体重与妊娠前体重之差。提取唾液样本的基因组DNA，采用TaqMan实时聚合酶链反应法对ADRB2 rs1042713 （G/A）和rs1042714 （C/G）多态性进行基因分型。在优势模型下使用Mann-Whitney U检验检验关联（P < 0.05）。该研究已获得机构伦理委员会批准（CAAE 70713423.8.0000.5258；批准号6.273.645）。从2024年3月到2025年5月，在巴西里约热内卢的一家大学医院进行了一项横断面研究。参与者为产后6周到12个月的成年产后妇女（=20岁）。孕前体重从孕妇怀孕手册和/或在结构化访谈中自我报告。目前的体重和身高通过人体测量评估获得。根据世界卫生组织的标准对孕前和目前的BMI进行分类。GWG计算为妊娠前体重与最终妊娠体重之差，PPWR计算为当前体重与妊娠前体重之差。提取唾液样本的基因组DNA，采用TaqMan实时聚合酶链反应法对ADRB2 rs1042713 （G/A）和rs1042714 （C/G）多态性进行基因分型。在优势模型下使用Mann-Whitney U检验检验关联（P < 0.05）。该研究已获得机构伦理委员会批准（CAAE 70713423.8.0000.5258；批准号6.273.645）。结果共有196名妇女和74名妇女分别进行了rs1042713和rs1042714多态性评估。中位年龄为29岁（IQR: 25-34）。携带rs1042713多态性的AG/AA基因型的女性目前的BMI值较低[27.99 vs 29.93 kg/m2；P = 0.048]且孕前BMI值较低[27.02 vs. 29.71 kg/m2；P = 0.029]。GWG组间无显著差异[12.0 vs. 10.0 kg；P >； 0.05]或PPWR [5.0 vs. 6.0 kg；P > 0.05]。对于rs1042714多态性，所有评估变量的基因型组间无显著差异（P > 0.05）。共有196名女性和74名女性分别进行了rs1042713和rs1042714多态性评估。中位年龄为29岁（IQR: 25-34）。携带rs1042713多态性的AG/AA基因型的女性目前的BMI值较低[27.99 vs 29.93 kg/m2；P = 0.048]且孕前BMI值较低[27.02 vs. 29.71 kg/m2；P = 0.029]。GWG组间无显著差异[12.0 vs. 10.0 kg；P >； 0.05]或PPWR [5.0 vs. 6.0 kg；P > 0.05]。对于rs1042714多态性，所有评估变量的基因型组间无显著差异（P > 0.05）。结论ADRB2 rs1042713多态性与母体肥胖相关，反映在孕前和当前的BMI上，但与GWG和PPWR无关。相反，未发现rs1042714与肥胖相关结局之间存在显著关联。ADRB2 rs1042713多态性与母体肥胖相关，这反映在孕前和当前的BMI上，但与GWG和PPWR无关。相反，未发现rs1042714与肥胖相关结局之间存在显著关联。

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CAHIERS DE NUTRITION ET DE DIETETIQUE NUTRITION & DIETETICS-

CiteScore

0.60

自引率

33.30%

发文量

审稿时长

65 days

期刊介绍： Les Cahiers de nutrition et de diététique sont le lieu de communication reconnu pour les médecins spécialistes de la nutrition, les diététiciens, les professionnels et les chercheurs de agro-alimentaire, les enseignants et les étudiants. Les Cahiers de nutrition et de diététique abordent les sujets se rapportant à la biologie générale, à la médecine et à la nutrition, aux aliments, aux comportements alimentaires, à la diététique pratique, ainsi que des thèmes variés : activité physique, apports nutritionnels conseillés, dénutrition, alcool, obésité de enfant, aliments à effet santé, plaisir alimentaire, restauration collective, goûters et collations, allergies alimentaires...