Association between endocannabinoids and body mass in women with severe obesity

IF 0.3 Q4 NUTRITION & DIETETICS

CAHIERS DE NUTRITION ET DE DIETETIQUE Pub Date : 2026-08-01 Epub Date: 2026-09-24 DOI:10.1016/j.cnd.2026.08.085

Alaine Victorino Gonçalves Valentim, Alessandra da Silva, Maria Beatriz Carvalho Fonseca Santos Salles, Julia Moreira Oliveira, Ellen Karine Lima de Matos, Natália dos Santos Souza, Larissa de Brito Fassarella, Letícia Alaburda de Araujo, Ísis Hara Trevenzoli, Eliane Lopes Rosado

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引用次数: 0

Abstract

Objective

The endocannabinoid system plays an important role in regulating energy balance and appears to be overactive in individuals with obesity. The objective of this study was to evaluate the association between plasma concentrations of endocannabinoids (eCBs) and indicators of adiposity, including body weight, body mass index (BMI), and waist circumference (WC), in women with severe obesity.

Methods

This is a cross-sectional observational study, approved by the Research Ethics Committee under approval number 5.621.915. Sixty-eight women with severe obesity were evaluated during the preoperative period for bariatric and metabolic surgery, treated by the Obesity and Bariatric and Metabolic Surgery Program (PROCIBA) at the Clementino Fraga Filho University Hospital of the Federal University of Rio de Janeiro (HUCFF/UFRJ), Brazil. Body weight, BMI, and WC were measured using standardized procedures. Plasma concentrations of anandamide (AEA), 2-arachidonoylglycerol (2-AG), palmitoylethanolamide (PEA), and oleoylethanolamide (OEA) were determined by high-performance liquid chromatography coupled with mass spectrometry at the Molecular Endocrinology Laboratory of the Institute of Biophysics/UFRJ. Spearman's correlation tests and multiple linear regression analyses were performed using R software version 4.5.2, with a significance level of 5%.

Results

The participants had a median age of 50.5 years (IQR = 18) and a mean BMI of 45.7 ± 6.1 kg/m². The eCB panel was significantly associated with BMI (P = 0.015), explaining 17.6% of its variability (R² = 0.176). Despite the significant overall effect, none of the biomarkers showed an independent association when analyzed separately. OEA was positively associated with total body weight (P = 0.04). There was no association with WC.

Conclusion

The profile of plasma endocannabinoids was associated with BMI, and OEA showed a positive correlation with total body weight in women with severe obesity. Further studies are needed to clarify the mechanisms underlying these associations and their role in the pathophysiology of obesity.

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内源性大麻素与严重肥胖妇女体重的关系

目的：内源性大麻素系统在调节能量平衡中起重要作用，在肥胖人群中表现为过度活跃。本研究的目的是评估严重肥胖女性血浆内源性大麻素（eCBs）浓度与肥胖指标（包括体重、体重指数（BMI）和腰围（WC））之间的关系。内源性大麻素系统在调节能量平衡方面起着重要作用，在肥胖人群中似乎过于活跃。本研究的目的是评估严重肥胖女性血浆内源性大麻素（eCBs）浓度与肥胖指标（包括体重、体重指数（BMI）和腰围（WC））之间的关系。方法：本研究为横断面观察性研究，经研究伦理委员会批准，批准号为5.621.915。在巴西里约热内卢联邦大学Clementino Fraga Filho大学医院（HUCFF/UFRJ）的肥胖、减肥和代谢手术项目（PROCIBA）中，对68名重度肥胖妇女进行术前减肥和代谢手术评估。采用标准化程序测量体重、BMI和WC。在UFRJ生物物理研究所分子内分泌实验室，采用高效液相色谱联用质谱法测定了血浆中anandamide （AEA）、2-花生四烯醇甘油（2-AG）、棕榈酰乙醇酰胺（PEA）和油基乙醇酰胺（OEA）的浓度。采用R软件4.5.2版进行Spearman相关检验和多元线性回归分析，显著性水平为5%。这是一项横断面观察性研究，经研究伦理委员会批准，批准号为5.621.915。在巴西里约热内卢联邦大学Clementino Fraga Filho大学医院（HUCFF/UFRJ）的肥胖、减肥和代谢手术项目（PROCIBA）中，对68名重度肥胖妇女进行术前减肥和代谢手术评估。采用标准化程序测量体重、BMI和WC。在UFRJ生物物理研究所分子内分泌实验室，采用高效液相色谱联用质谱法测定了血浆中anandamide （AEA）、2-花生四烯醇甘油（2-AG）、棕榈酰乙醇酰胺（PEA）和油基乙醇酰胺（OEA）的浓度。采用R软件4.5.2版进行Spearman相关检验和多元线性回归分析，显著性水平为5%。结果参与者的中位年龄为50.5岁（IQR = 18），平均BMI为45.7±6.1 kg/m2。eCB组与BMI显著相关（P = 0.015），解释了17.6%的变异（R2 = 0.176）。尽管整体效果显著，但在单独分析时，没有一种生物标志物显示出独立的关联。OEA与总体重呈正相关（P = 0.04）。与WC无关。参与者的中位年龄为50.5岁（IQR = 18），平均BMI为45.7±6.1 kg/m2。eCB组与BMI显著相关（P = 0.015），解释了17.6%的变异（R2 = 0.176）。尽管整体效果显著，但在单独分析时，没有一种生物标志物显示出独立的关联。OEA与总体重呈正相关（P = 0.04）。与WC无关。结论重度肥胖女性血浆内源性大麻素水平与BMI呈正相关，OEA与总体重呈正相关。需要进一步的研究来阐明这些关联的机制及其在肥胖病理生理中的作用。血浆内源性大麻素与BMI相关，严重肥胖女性的OEA与总体重呈正相关。需要进一步的研究来阐明这些关联的机制及其在肥胖病理生理中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CAHIERS DE NUTRITION ET DE DIETETIQUE NUTRITION & DIETETICS-

CiteScore

0.60

自引率

33.30%

发文量

审稿时长

65 days

期刊介绍： Les Cahiers de nutrition et de diététique sont le lieu de communication reconnu pour les médecins spécialistes de la nutrition, les diététiciens, les professionnels et les chercheurs de agro-alimentaire, les enseignants et les étudiants. Les Cahiers de nutrition et de diététique abordent les sujets se rapportant à la biologie générale, à la médecine et à la nutrition, aux aliments, aux comportements alimentaires, à la diététique pratique, ainsi que des thèmes variés : activité physique, apports nutritionnels conseillés, dénutrition, alcool, obésité de enfant, aliments à effet santé, plaisir alimentaire, restauration collective, goûters et collations, allergies alimentaires...