Association of LEP rs7799039 and LEPR rs1137101 polymorphisms with substantial postpartum weight retention in women attended by the Brazilian public health system

IF 0.3 Q4 NUTRITION & DIETETICS

CAHIERS DE NUTRITION ET DE DIETETIQUE Pub Date : 2026-08-01 Epub Date: 2026-09-24 DOI:10.1016/j.cnd.2026.08.061

Ana Clara Fonseca, Ana Sophia Lacerda, Manuela Barreto, Luiza Barreto Fonseca, Maria Luiza Azeredo Britto, Giovana Andriole, Maira Coppola Auler, José Guilherme de Santana Santos, Felipe Rabelo Costa, Katherine Bittencourt, Karina dos Santos

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引用次数: 0

Abstract

Objective

To evaluate the association between LEP rs7799039 and LEPR rs1137101 polymorphisms and substantial postpartum weight retention (SPPWR) in women attended by the Brazilian Public Health System.

Methods

This cross-sectional study is part of an ongoing observational investigation conducted with postpartum adult women, between 42 and 365 days after delivery, at a University Hospital in Rio de Janeiro, Brazil, between March 2024 and May 2025. Pre-pregnancy weight was obtained from maternal records or self-report. Current weight and height were measured, and BMI was classified according to World Health Organization criteria. SPPWR was defined as a difference of =5 kg between current and pre-pregnancy weight. Buccal cell samples were obtained for DNA extraction and genotyping for LEP rs7799039 and LEPR rs1137101 polymorphisms using real-time polymerase chain reaction (PCR). Associations were tested under overdominant models using the Pearson's chi-square test (P < 0.05). The study was approved by the institutional Ethics Committee (CAAE 70713423.8.0000.5258; approval number 6.273.645).

Results

A total of 227 and 231 women were evaluated for LEPR rs1137101 and LEP rs7799039, respectively. Median age was 29 years (IQR: 25–34). A significant association was observed between LEPR rs1137101 and SPPWR, with a higher frequency among women carrying the heterozygous genotype (AG) than among homozygous carriers (40.7% vs. 26.1%; P = 0.021). No association was found between LEPR rs1137101 and the current BMI category (74.8% vs. 67.9%; P = 0.249). For LEP rs7799039, no significant associations were observed with the current BMI category (75.6% vs. 68.5%; P = 0.252) or SPPWR (34.2% vs. 33.8%; P = 0.952).

Conclusion

The LEPR rs1137101 polymorphism was associated with SPPWR but not with the current BMI category. No associations were observed between the LEP rs7799039 polymorphism and either SPPWR or current BMI category, supporting a potential role of leptin signaling in postpartum weight regulation.

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巴西公共卫生系统参与的妇女中，LEP rs7799039和LEPR rs1137101多态性与产后体重保持的关系

目的探讨巴西公共卫生系统住院妇女LEP rs7799039和LEPR rs1137101多态性与产后体重潴留（SPPWR）的关系。评估巴西公共卫生系统参与的妇女中LEP rs7799039和LEPR rs1137101多态性与产后体重保持（SPPWR）之间的关系。方法：本横断面研究是一项正在进行的观察性调查的一部分，该调查于2024年3月至2025年5月在巴西里约热内卢里约热内卢大学医院对产后42至365天的成年妇女进行。孕前体重由产妇记录或自我报告获得。测量了目前的体重和身高，并根据世界卫生组织的标准对BMI进行了分类。SPPWR定义为当前体重与孕前体重差=5 kg。获取颊细胞样本进行DNA提取，利用实时聚合酶链反应（real-time polymerase chain reaction， PCR）对LEP rs7799039和LEPR rs1137101进行基因分型。使用Pearson's卡方检验（P < 0.05）对超优势模型下的关联进行检验。该研究已获得机构伦理委员会批准（CAAE 70713423.8.0000.5258；批准号6.273.645）。这项横断面研究是一项正在进行的观察性调查的一部分，该调查是在2024年3月至2025年5月期间在巴西里约热内卢里约热内卢的一家大学医院对产后42至365天的成年妇女进行的。孕前体重由产妇记录或自我报告获得。测量了目前的体重和身高，并根据世界卫生组织的标准对BMI进行了分类。SPPWR定义为当前体重与孕前体重差=5 kg。获取颊细胞样本进行DNA提取，利用实时聚合酶链反应（real-time polymerase chain reaction， PCR）对LEP rs7799039和LEPR rs1137101进行基因分型。使用Pearson's卡方检验（P < 0.05）对超优势模型下的关联进行检验。该研究已获得机构伦理委员会批准（CAAE 70713423.8.0000.5258；批准号6.273.645）。结果共有227名妇女和231名妇女分别检测了LEPR rs1137101和LEP rs7799039。中位年龄29岁（IQR: 25-34）。LEPR rs1137101与SPPWR之间存在显著相关性，携带杂合基因型（AG）的女性的频率高于携带纯合基因型的女性（40.7%比26.1%,P = 0.021）。未发现LEPR rs1137101与当前BMI类别相关（74.8% vs. 67.9%; P = 0.249）。对于LEP rs7799039，未观察到与当前BMI类别（75.6% vs. 68.5%, P = 0.252）或SPPWR （34.2% vs. 33.8%, P = 0.952）有显著相关性。共有227名妇女和231名妇女分别进行了LEPR rs1137101和LEP rs7799039的评估。中位年龄29岁（IQR: 25-34）。LEPR rs1137101与SPPWR之间存在显著相关性，携带杂合基因型（AG）的女性的频率高于携带纯合基因型的女性（40.7%比26.1%,P = 0.021）。未发现LEPR rs1137101与当前BMI类别相关（74.8% vs. 67.9%; P = 0.249）。对于LEP rs7799039，未观察到与当前BMI类别（75.6% vs. 68.5%, P = 0.252）或SPPWR （34.2% vs. 33.8%, P = 0.952）有显著相关性。结论LEPR rs1137101多态性与SPPWR相关，但与当前BMI分类无关。未观察到LEP rs7799039多态性与SPPWR或当前BMI类别之间的关联，支持瘦素信号在产后体重调节中的潜在作用。LEPR rs1137101多态性与SPPWR相关，但与目前的BMI类别无关。未观察到LEP rs7799039多态性与SPPWR或当前BMI类别之间的关联，支持瘦素信号在产后体重调节中的潜在作用。

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来源期刊

CAHIERS DE NUTRITION ET DE DIETETIQUE NUTRITION & DIETETICS-

CiteScore

0.60

自引率

33.30%

发文量

审稿时长

65 days

期刊介绍： Les Cahiers de nutrition et de diététique sont le lieu de communication reconnu pour les médecins spécialistes de la nutrition, les diététiciens, les professionnels et les chercheurs de agro-alimentaire, les enseignants et les étudiants. Les Cahiers de nutrition et de diététique abordent les sujets se rapportant à la biologie générale, à la médecine et à la nutrition, aux aliments, aux comportements alimentaires, à la diététique pratique, ainsi que des thèmes variés : activité physique, apports nutritionnels conseillés, dénutrition, alcool, obésité de enfant, aliments à effet santé, plaisir alimentaire, restauration collective, goûters et collations, allergies alimentaires...