Association between the FTO rs9939609 polymorphism and energy, macronutrient, and fiber intake in adults with obesity: Preliminary results of a systematic review of observational studies

IF 0.3 Q4 NUTRITION & DIETETICS

CAHIERS DE NUTRITION ET DE DIETETIQUE Pub Date : 2026-08-01 Epub Date: 2026-09-24 DOI:10.1016/j.cnd.2026.08.079

Matheus Maia Soares, Hilana Moreira Paiva, Sandy Maira Almeida de Andrade, Alessandra Silva, Flavia Lucia Conceição, Fernanda Cristina C. Mattos, João Regis Ivar Carneiro

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引用次数: 0

Abstract

Objective

The influence of the FTO rs9939609 polymorphism on dietary intake in adults with obesity remains poorly understood. Thus, the objective of this study is to systematically review the association between the FTO rs9939609 polymorphism and total energy, macronutrient (fat, carbohydrate, and protein), and fiber intake in adults with obesity.

Methods

This systematic review was conducted in accordance with PRISMA 2020 guidelines and registered with PROSPERO (CRD420261344866). Electronic searches were performed in MEDLINE, EMBASE, and Scopus for studies published between 2015 and 2026, supplemented by manual screening of reference lists. Eligibility criteria followed the PECOS framework: adults with obesity (BMI ≥ 30 kg/m²); FTO rs9939609 genotyping as exposure; comparison between risk allele carriers (AA/AT) versus non-carriers (TT); outcomes included total energy, macronutrient, micronutrient, and fiber intake; observational study designs (cross-sectional, cohort, or case-control). Studies in children or animals and those lacking extractable data were excluded. Titles and abstracts were screened independently by three reviewers, with discrepancies resolved by consensus. The Rayyan software was used for duplicate management.

Results

A total of 1,084 articles were identified, of which 421 duplicates were removed, resulting in 663 articles screened by title and abstract. Of these, 20 articles were read in full, and 3 met the eligibility criteria and were included. All included studies are cross-sectional; two were conducted in Brazil and one in Norway. A total of 276 individuals were evaluated (63.7% women), with mean or median BMI ranging from 42.8 to 46.9 kg/m². One study reported higher energy, protein, and lipid intakes in risk allele carriers (AA and AT) compared to TT homozygotes, but only in participants under 45 years, suggesting an agemodulating effect. In one study, protein intake per kilogram of body weight was significantly lower in TT carriers. In one study, no significant association was observed between FTO rs9939609 genotypes and total energy, carbohydrate, fat, or fiber intake.

Conclusion

These preliminary results suggest that the FTO rs9939609 polymorphism may be associated with energy, lipid, and protein intake, and that this relationship may be age-dependent. Further studies are needed to confirm this association.

查看原文本刊更多论文

FTO rs9939609多态性与成年肥胖患者能量、宏量营养素和纤维摄入量之间的关系：一项观察性研究的系统综述的初步结果

目的FTO rs9939609多态性对成人肥胖患者膳食摄入的影响尚不清楚。因此，本研究的目的是系统地回顾FTO rs9939609多态性与肥胖成人总能量、常量营养素（脂肪、碳水化合物和蛋白质）和纤维摄入量之间的关系。FTO rs9939609多态性对肥胖成人饮食摄入的影响尚不清楚。因此，本研究的目的是系统地回顾FTO rs9939609多态性与肥胖成人总能量、常量营养素（脂肪、碳水化合物和蛋白质）和纤维摄入量之间的关系。方法本系统评价按照PRISMA 2020指南进行，并在PROSPERO注册（CRD420261344866）。在MEDLINE、EMBASE和Scopus中对2015年至2026年间发表的研究进行电子检索，并辅以人工筛选参考文献列表。入选标准遵循PECOS框架：肥胖成人（BMI≥30 kg/m2）；FTO rs9939609基因分型暴露；风险等位基因携带者（AA/AT）与非携带者（TT）的比较；结果包括总能量、常量营养素、微量营养素和纤维摄入量；观察性研究设计（横断面、队列或病例对照）。对儿童或动物的研究以及缺乏可提取数据的研究被排除在外。标题和摘要由三位审稿人独立筛选，差异通过协商一致解决。使用Rayyan软件进行副本管理。该系统评价按照PRISMA 2020指南进行，并在PROSPERO注册（CRD420261344866）。在MEDLINE、EMBASE和Scopus中对2015年至2026年间发表的研究进行电子检索，并辅以人工筛选参考文献列表。入选标准遵循PECOS框架：肥胖成人（BMI≥30 kg/m2）；FTO rs9939609基因分型暴露；风险等位基因携带者（AA/AT）与非携带者（TT）的比较；结果包括总能量、常量营养素、微量营养素和纤维摄入量；观察性研究设计（横断面、队列或病例对照）。对儿童或动物的研究以及缺乏可提取数据的研究被排除在外。标题和摘要由三位审稿人独立筛选，差异通过协商一致解决。使用Rayyan软件进行副本管理。结果共筛选出1084篇文献，剔除重复421篇，按标题和摘要筛选的文献共663篇。其中，20篇文章被完整阅读，3篇符合入选标准。所有纳入的研究都是横断面的；两项研究在巴西进行，一项在挪威进行。共有276人被评估（63.7%为女性），平均或中位BMI在42.8至46.9 kg/m2之间。一项研究报告，与TT纯合子相比，风险等位基因携带者（AA和AT）的能量、蛋白质和脂质摄入量更高，但仅限于45岁以下的参与者，这表明存在年龄调节作用。在一项研究中，TT携带者每公斤体重的蛋白质摄入量明显较低。在一项研究中，FTO rs9939609基因型与总能量、碳水化合物、脂肪或纤维摄入量之间没有显著关联。共筛选出1084篇文章，删除重复421篇，按标题和摘要筛选出663篇。其中，20篇文章被完整阅读，3篇符合入选标准。所有纳入的研究都是横断面的；两项研究在巴西进行，一项在挪威进行。共有276人被评估（63.7%为女性），平均或中位BMI在42.8至46.9 kg/m2之间。一项研究报告，与TT纯合子相比，风险等位基因携带者（AA和AT）的能量、蛋白质和脂质摄入量更高，但仅限于45岁以下的参与者，这表明存在年龄调节作用。在一项研究中，TT携带者每公斤体重的蛋白质摄入量明显较低。在一项研究中，FTO rs9939609基因型与总能量、碳水化合物、脂肪或纤维摄入量之间没有显著关联。结论FTO rs9939609多态性可能与能量、脂质和蛋白质摄入有关，且这种关系可能与年龄相关。需要进一步的研究来证实这种关联。这些初步结果表明，FTO rs9939609多态性可能与能量、脂质和蛋白质摄入有关，并且这种关系可能与年龄有关。需要进一步的研究来证实这种关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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CAHIERS DE NUTRITION ET DE DIETETIQUE NUTRITION & DIETETICS-

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0.60

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33.30%

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审稿时长

65 days

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