Disordered eating behaviors are correlated with leptin-related gene expression patterns and increased adiposity in women with systemic lupus erythematosus

IF 0.3 Q4 NUTRITION & DIETETICS

CAHIERS DE NUTRITION ET DE DIETETIQUE Pub Date : 2026-08-01 Epub Date: 2026-09-24 DOI:10.1016/j.cnd.2026.08.099

Jhulia Caroline Nunes Leal da Mota, Beatriz Garcia Carvalho, Amanda Alves Ribeiro, Lucas Moura Carvalho, Bruno Gualano, Eduardo Ferreira Borba, Carolina Nicoletti Ferreira Fino

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引用次数: 0

Abstract

Objectives

This study aimed to investigate the association between disordered eating behaviors, leptin (LEP) gene expression, serum leptin levels, and body composition parameters in women with SLE.

Methods

Twenty-nine women (age 36.52 ± 5.64 years) with SLE in remission (Systemic Lupus Erythematosus Disease Activity Index [SLEDAI] ≤ 4) were included in this cross-sectional analysis. The study was approved by the Research Ethics Committee of Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (Certificate of Presentation for Ethical Consideration No. 86418824.6.0000.0068). Eating behavior was assessed using the Disordered Eating Attitude Scale (DEAS). Body mass index (BMI), waist circumference (WC), fat mass percentage (FM), serum leptin levels, and LEP gene expression were analyzed. Correlations between variables were evaluated using Spearman's correlation.

Results

Higher DEAS scores were positively associated with LEP expression (r = 0.646; P < 0.001), serum leptin levels (r = 0.492; P = 0.007), BMI (r = 0.580; P = 0.001), WC (r = 0.554; P = 0.002), and FM (r = 0.445; P = 0.016).

Conclusion

Higher disordered eating behavior scores were positively correlated with greater adiposity, elevated serum leptin levels, and increased LEP gene expression in women with SLE. Collectively, these findings suggest that disordered eating patterns may reflect an interaction between adiposity and leptin-mediated metabolic-inflammatory pathways in SLE. Understanding these interactions may contribute to more targeted nutritional and metabolic management strategies in this population. All authors declare no conflicts of interest.

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紊乱的饮食行为与瘦素相关基因表达模式和系统性红斑狼疮女性肥胖增加相关

目的探讨女性SLE患者饮食失调、瘦素（LEP）基因表达、血清瘦素水平和体成分参数之间的关系。本研究旨在探讨女性SLE患者饮食失调行为、瘦素（LEP）基因表达、血清瘦素水平和体成分参数之间的关系。方法选取系统性红斑狼疮疾病活动指数(SLEDAI)≤4的缓解期SLE患者29例（年龄36.52±5.64岁）。该研究已获得圣保罗大学医学院医院Clínicas研究伦理委员会的批准（伦理考虑陈述证书号：86418824.6.00000 .0068）。饮食行为采用饮食失调态度量表（DEAS）进行评估。分析体重指数（BMI）、腰围（WC）、脂肪质量百分比（FM）、血清瘦素水平和LEP基因表达。变量间的相关性采用Spearman相关法进行评估。本横断面分析纳入29例SLE缓解期（系统性红斑狼疮疾病活动指数[SLEDAI]≤4）女性（年龄36.52±5.64岁）。该研究已获得圣保罗大学医学院医院Clínicas研究伦理委员会的批准（伦理考虑陈述证书号：86418824.6.00000 .0068）。饮食行为采用饮食失调态度量表（DEAS）进行评估。分析体重指数（BMI）、腰围（WC）、脂肪质量百分比（FM）、血清瘦素水平和LEP基因表达。变量间的相关性采用Spearman相关法进行评估。结果高DEAS评分与LEP表达（r = 0.646; P < 0.001）、血清瘦素水平（r = 0.492; P = 0.007）、BMI （r = 0.580; P = 0.001）、WC （r = 0.554; P = 0.002）、FM （r = 0.445; P = 0.016）呈正相关。较高的DEAS评分与LEP表达（r = 0.646; P < 0.001）、血清瘦素水平（r = 0.492; P = 0.007）、BMI （r = 0.580; P = 0.001）、WC （r = 0.554; P = 0.002）、FM （r = 0.445; P = 0.016）呈正相关。结论饮食失调行为评分越高，SLE患者肥胖程度越高，血清瘦素水平升高，LEP基因表达增加。总的来说，这些发现表明，紊乱的饮食模式可能反映了SLE中肥胖和瘦素介导的代谢炎症途径之间的相互作用。了解这些相互作用可能有助于在这一人群中制定更有针对性的营养和代谢管理策略。所有作者声明无利益冲突。在SLE患者中，较高的饮食失调行为评分与较高的肥胖、血清瘦素水平升高和LEP基因表达增加呈正相关。总的来说，这些发现表明，紊乱的饮食模式可能反映了SLE中肥胖和瘦素介导的代谢炎症途径之间的相互作用。了解这些相互作用可能有助于在这一人群中制定更有针对性的营养和代谢管理策略。所有作者声明无利益冲突。

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来源期刊

CAHIERS DE NUTRITION ET DE DIETETIQUE NUTRITION & DIETETICS-

CiteScore

0.60

自引率

33.30%

发文量

审稿时长

65 days

期刊介绍： Les Cahiers de nutrition et de diététique sont le lieu de communication reconnu pour les médecins spécialistes de la nutrition, les diététiciens, les professionnels et les chercheurs de agro-alimentaire, les enseignants et les étudiants. Les Cahiers de nutrition et de diététique abordent les sujets se rapportant à la biologie générale, à la médecine et à la nutrition, aux aliments, aux comportements alimentaires, à la diététique pratique, ainsi que des thèmes variés : activité physique, apports nutritionnels conseillés, dénutrition, alcool, obésité de enfant, aliments à effet santé, plaisir alimentaire, restauration collective, goûters et collations, allergies alimentaires...