Interaction of TAS2R38 gene haplotypes (AVV and PAV) with dietary intake and their relationship with cardiometabolic risk in a Mexican adult population

IF 0.3 Q4 NUTRITION & DIETETICS

CAHIERS DE NUTRITION ET DE DIETETIQUE Pub Date : 2026-08-01 Epub Date: 2026-09-24 DOI:10.1016/j.cnd.2026.08.096

Alma Daniela Olvera Martínez, Sonia Roman, Arturo Panduro, Omar Ramos-Lopez

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The aim of this study was to analyze the interaction of TAS2R38 haplotypes (AVV and PAI) with dietary intake and their relationship with cardiometabolic risk in Mexican adults.</div></div><div>Cardiovascular diseases (CVD) are a leading cause of mortality and represent a major disease burden in Mexico. Diets high in fat, sugars, and sodium influence the onset and development of cardiometabolic alterations; however, their effect on health may depend on individual genetics. Variations in the TAS2R38 gene have been shown to influence food preferences, which may impact health status. The aim of this study was to analyze the interaction of TAS2R38 haplotypes (AVV and PAI) with dietary intake and their relationship with cardiometabolic risk in Mexican adults.</div><div><h3>Methods</h3><div>A secondary cross-sectional analytical study was conducted with 375 adults of both sexes from Guadalajara (Jalisco). Habitual dietary intake was assessed using validated 3-day 24-hour recalls. Allelic discrimination assays were used for polymorphism determination. Chi-<sup>2</sup> tests and logistic regression were applied. A previously approved database by a Research Ethics Committee (ID#HC141/09) was used, in accordance with the principles of the Declaration of Helsinki, ensuring participant confidentiality, anonymity, and the exclusive use of the information for scientific and academic purposes.</div></div><div>A secondary cross-sectional analytical study was conducted with 375 adults of both sexes from Guadalajara (Jalisco). Habitual dietary intake was assessed using validated 3-day 24-hour recalls. Allelic discrimination assays were used for polymorphism determination. Chi-<sup>2</sup> tests and logistic regression were applied. 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引用次数: 0

Abstract

Background

Cardiovascular diseases (CVD) are a leading cause of mortality and represent a major disease burden in Mexico. Diets high in fat, sugars, and sodium influence the onset and development of cardiometabolic alterations; however, their effect on health may depend on individual genetics. Variations in the TAS2R38 gene have been shown to influence food preferences, which may impact health status. The aim of this study was to analyze the interaction of TAS2R38 haplotypes (AVV and PAI) with dietary intake and their relationship with cardiometabolic risk in Mexican adults.

Methods

A secondary cross-sectional analytical study was conducted with 375 adults of both sexes from Guadalajara (Jalisco). Habitual dietary intake was assessed using validated 3-day 24-hour recalls. Allelic discrimination assays were used for polymorphism determination. Chi-² tests and logistic regression were applied. A previously approved database by a Research Ethics Committee (ID#HC141/09) was used, in accordance with the principles of the Declaration of Helsinki, ensuring participant confidentiality, anonymity, and the exclusive use of the information for scientific and academic purposes.

Results

Significant interactions were identified between the AVV and PAI haplotypes in relation to nutrient intake. Specifically, individuals with the AVV/AVV haplotype showed that, as energy intake increased, total cholesterol levels increased compared to carriers of the PAI haplotype (P = 0.029). Consistently, higher lipid intake (g) in this same group was associated with higher total cholesterol concentrations (P = 0.033). Likewise, in individuals with the AVV/AVV haplotype, a higher percentage of dietary lipids was significantly associated with higher levels of both diastolic and systolic blood pressure (P = 0.019 and p = 0.010, respectively). Finally, within this group, higher consumption of fruit equivalents was associated with higher glucose levels (P = 0.034).

Conclusions

TAS2R38 haplotypes (AVV and PAI) are significantly associated with dietary intake and cardiometabolic risk in Mexican adults, reflecting the influence of genetic variability on food preferences and health, and supporting the use of genetic profiling for personalized nutrition strategies.

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墨西哥成年人TAS2R38基因单倍型（AVV和PAV）与饮食摄入的相互作用及其与心脏代谢风险的关系

背景：在墨西哥，心血管疾病（CVD）是导致死亡的主要原因，也是主要的疾病负担。高脂肪、高糖和高钠饮食影响心脏代谢改变的发生和发展；然而，它们对健康的影响可能取决于个体的基因。TAS2R38基因的变异已被证明会影响食物偏好，从而影响健康状况。本研究的目的是分析墨西哥成年人TAS2R38单倍型（AVV和PAI）与饮食摄入的相互作用及其与心脏代谢风险的关系。心血管疾病是导致死亡的主要原因，是墨西哥的一个主要疾病负担。高脂肪、高糖和高钠饮食影响心脏代谢改变的发生和发展；然而，它们对健康的影响可能取决于个体的基因。TAS2R38基因的变异已被证明会影响食物偏好，从而影响健康状况。本研究的目的是分析墨西哥成年人TAS2R38单倍型（AVV和PAI）与饮食摄入的相互作用及其与心脏代谢风险的关系。方法对来自瓜达拉哈拉（哈利斯科州）的375名成年男女进行二次横断面分析研究。采用3天24小时回忆法评估习惯性饮食摄入。采用等位基因鉴别法测定多态性。采用Chi-2检验和logistic回归。根据《赫尔辛基宣言》的原则，使用研究伦理委员会先前批准的数据库（ID#HC141/09），确保参与者保密、匿名，并将信息独家用于科学和学术目的。对来自瓜达拉哈拉（哈利斯科州）的375名男女成年人进行了二次横断面分析研究。采用3天24小时回忆法评估习惯性饮食摄入。采用等位基因鉴别法测定多态性。采用Chi-2检验和logistic回归。根据《赫尔辛基宣言》的原则，使用研究伦理委员会先前批准的数据库（ID#HC141/09），确保参与者保密、匿名，并将信息独家用于科学和学术目的。结果AVV和PAI单倍型在营养摄入方面存在显著的交互作用。具体来说，与PAI单倍型携带者相比，携带AVV/AVV单倍型的个体显示，随着能量摄入的增加，总胆固醇水平升高（P = 0.029）。在同一组中，较高的脂质摄入量(g)与较高的总胆固醇浓度相关（P = 0.033）。同样，在具有AVV/AVV单倍型的个体中，较高的饮食脂质百分比与较高的舒张压和收缩压水平显著相关（P分别= 0.019和P = 0.010）。最后，在这一组中，水果等价物的消耗越多，葡萄糖水平越高（P = 0.034）。AVV和PAI单倍型与营养摄入量之间存在显著的相互作用。具体来说，与PAI单倍型携带者相比，携带AVV/AVV单倍型的个体显示，随着能量摄入的增加，总胆固醇水平升高（P = 0.029）。在同一组中，较高的脂质摄入量(g)与较高的总胆固醇浓度相关（P = 0.033）。同样，在具有AVV/AVV单倍型的个体中，较高的饮食脂质百分比与较高的舒张压和收缩压水平显著相关（P分别= 0.019和P = 0.010）。最后，在这一组中，水果等价物的消耗越多，葡萄糖水平越高（P = 0.034）。结论stas2r38单倍型（AVV和PAI）与墨西哥成年人的饮食摄入和心脏代谢风险显著相关，反映了遗传变异对食物偏好和健康的影响，并支持将遗传谱用于个性化营养策略。TAS2R38单倍型（AVV和PAI）与墨西哥成年人的饮食摄入和心脏代谢风险显著相关，反映了遗传变异对食物偏好和健康的影响，并支持将遗传谱用于个性化营养策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CAHIERS DE NUTRITION ET DE DIETETIQUE NUTRITION & DIETETICS-

CiteScore

0.60

自引率

33.30%

发文量

审稿时长

65 days

期刊介绍： Les Cahiers de nutrition et de diététique sont le lieu de communication reconnu pour les médecins spécialistes de la nutrition, les diététiciens, les professionnels et les chercheurs de agro-alimentaire, les enseignants et les étudiants. Les Cahiers de nutrition et de diététique abordent les sujets se rapportant à la biologie générale, à la médecine et à la nutrition, aux aliments, aux comportements alimentaires, à la diététique pratique, ainsi que des thèmes variés : activité physique, apports nutritionnels conseillés, dénutrition, alcool, obésité de enfant, aliments à effet santé, plaisir alimentaire, restauration collective, goûters et collations, allergies alimentaires...