Association of the FTO rs9939609 polymorphism with obesity and postpartum weight retention in Brazilian women

IF 0.3 Q4 NUTRITION & DIETETICS

CAHIERS DE NUTRITION ET DE DIETETIQUE Pub Date : 2026-08-01 Epub Date: 2026-09-24 DOI:10.1016/j.cnd.2026.08.058

José Guilherme de Santana Santos, Ana Sophia Soares Pessoa Nobre de Lacerda, Ana Clara Fonseca da Silva Gonçalves, Manuela Paz Barreto, Maria Luiza Azeredo Britto, Luiza Barreto Fonseca, Maira Coppola Auler, Felipe Rabelo Costa, Katherine Bittencourt Mendes Leitão de Jesus, Ana Carolina Proença da Fonseca, Karina dos Santos

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引用次数: 0

Abstract

Objective

To investigate the association between the rs9939609 polymorphism of the FTO gene, obesity, and postpartum weight retention among women during the first year after childbirth.

Methods

A cross-sectional study was conducted among adult women (=20 years) between 6 weeks and 12 months postpartum who had experienced a singleton pregnancy. Participants were recruited from a university hospital in Rio de Janeiro, Brazil, between March 2024 and June 2026. Women who were pregnant at the time of data collection, diagnosed with HIV infection, or unable to complete the interview were excluded. Sociodemographic, clinical, obstetric, and anthropometric information was obtained through interviews and medical records. Postpartum weight retention (PPWR) was calculated as the difference between current weight and pre-pregnancy weight and was considered substantial when =5 kg. Obesity was defined according to current body mass index. Genotyping of the rs9939609 polymorphism was performed using real-time PCR analysis of genomic DNA extracted from saliva samples. Associations were examined under codominant, dominant, and recessive genetic models, adopting a significance level of P < 0.05. The study was approved by the Research Ethics Committee (CAAE 70713423.8.0000.5258; approval no. 6.273.645).

Preliminary results

A total of 228 women were included. The prevalence of current obesity was significantly higher among women carrying the AA genotype (56.8%) compared with those carrying the TT or TA genotypes (39.7%) (P = 0.039). Women with the AA genotype also exhibited greater median PPWR (8.05 kg) than those with TT (4.50 kg) or TA (4.88 kg) genotypes (P = 0.014). Furthermore, substantial PPWR was more frequent among AA carriers (78.6%) than among women with TT or TA genotypes (49.5%) (P = 0.006). Despite this unfavorable nutritional profile, most participants reported not receiving nutritional care during prenatal follow-up (67.0%) or the postpartum period (92.1%).

Conclusions

The AA genotype of the FTO rs9939609 polymorphism was associated with obesity and greater postpartum weight retention. Considering the limited nutritional follow-up observed in this population, strategies to improve nutritional care during pregnancy and the postpartum period may contribute to preventing adverse weight outcomes.

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FTO rs9939609多态性与巴西女性肥胖和产后体重保持的关系

目的探讨产后1年妇女FTO基因rs9939609多态性与肥胖及产后体重保持的关系。目的：探讨FTO基因rs9939609多态性与产后一年内肥胖和产后体重保持的关系。方法对产后6周至12个月的单胎妊娠成年妇女（20岁）进行横断面研究。参与者是在2024年3月至2026年6月期间从巴西里约热内卢的一家大学医院招募的。在收集数据时怀孕、被诊断为艾滋病毒感染或无法完成访谈的妇女被排除在外。通过访谈和医疗记录获得了社会人口学、临床、产科和人体测量学信息。产后体重保持（PPWR）以当前体重与孕前体重之差计算，当=5 kg时被认为是实质性的。肥胖是根据目前的身体质量指数来定义的。rs9939609多态性的基因分型采用实时荧光定量PCR对唾液样本中提取的基因组DNA进行分析。在共显性、显性和隐性遗传模型下检验相关性，采用显著性水平P <； 0.05。本研究已获得研究伦理委员会批准(CAAE: 70713423.8.0000.5258；6.273.645)。一项横断面研究在产后6周到12个月之间经历过单胎妊娠的成年妇女（=20岁）中进行。参与者是在2024年3月至2026年6月期间从巴西里约热内卢的一家大学医院招募的。在收集数据时怀孕、被诊断为艾滋病毒感染或无法完成访谈的妇女被排除在外。通过访谈和医疗记录获得了社会人口学、临床、产科和人体测量学信息。产后体重保持（PPWR）以当前体重与孕前体重之差计算，当=5 kg时被认为是实质性的。肥胖是根据目前的身体质量指数来定义的。rs9939609多态性的基因分型采用实时荧光定量PCR对唾液样本中提取的基因组DNA进行分析。在共显性、显性和隐性遗传模型下检验相关性，采用显著性水平P <； 0.05。本研究已获得研究伦理委员会批准(CAAE: 70713423.8.0000.5258；6.273.645)。初步结果共纳入228名女性。AA基因型女性的肥胖患病率（56.8%）明显高于TT或TA基因型女性（39.7%）（P = 0.039）。AA基因型女性的中位PPWR （8.05 kg）也高于TT （4.50 kg）或TA （4.88 kg）基因型女性（P = 0.014）。此外，AA携带者（78.6%）的PPWR发生率高于TT或TA基因型女性（49.5%）（P = 0.006）。尽管营养状况不佳，但大多数参与者报告在产前随访（67.0%）或产后随访（92.1%）期间未接受营养护理。总共包括228名妇女。AA基因型女性的肥胖患病率（56.8%）明显高于TT或TA基因型女性（39.7%）（P = 0.039）。AA基因型女性的中位PPWR （8.05 kg）也高于TT （4.50 kg）或TA （4.88 kg）基因型女性（P = 0.014）。此外，AA携带者（78.6%）的PPWR发生率高于TT或TA基因型女性（49.5%）（P = 0.006）。尽管营养状况不佳，但大多数参与者报告在产前随访（67.0%）或产后随访（92.1%）期间未接受营养护理。结论FTO rs9939609基因多态性AA型与肥胖及产后体重潴留有关。考虑到在该人群中观察到的营养随访有限，改善孕期和产后营养护理的策略可能有助于预防不良体重结局。FTO rs9939609多态性的AA基因型与肥胖和产后体重潴留有关。考虑到在该人群中观察到的营养随访有限，改善孕期和产后营养护理的策略可能有助于预防不良体重结局。

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来源期刊

CAHIERS DE NUTRITION ET DE DIETETIQUE NUTRITION & DIETETICS-

CiteScore

0.60

自引率

33.30%

发文量

审稿时长

65 days

期刊介绍： Les Cahiers de nutrition et de diététique sont le lieu de communication reconnu pour les médecins spécialistes de la nutrition, les diététiciens, les professionnels et les chercheurs de agro-alimentaire, les enseignants et les étudiants. Les Cahiers de nutrition et de diététique abordent les sujets se rapportant à la biologie générale, à la médecine et à la nutrition, aux aliments, aux comportements alimentaires, à la diététique pratique, ainsi que des thèmes variés : activité physique, apports nutritionnels conseillés, dénutrition, alcool, obésité de enfant, aliments à effet santé, plaisir alimentaire, restauration collective, goûters et collations, allergies alimentaires...