Association between the A49P polymorphism (TAS2R38) and chili consumption in Mexican adult population

IF 0.3 Q4 NUTRITION & DIETETICS

CAHIERS DE NUTRITION ET DE DIETETIQUE Pub Date : 2026-08-01 Epub Date: 2026-09-24 DOI:10.1016/j.cnd.2026.08.066

Alma Daniela Olvera Martínez, Genaro Rodriguez-Uribe, José de Jesús Manríquez Torres, Dr Omar Ramos-Lopez

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Abstract

Background/objective

Chili is a distinctive component of Mexican culture and diet since pre-Hispanic times. However, the effect of chili and other foods on health may vary according to individual tolerance, influenced by various factors, including genetics. The aim of this study was to evaluate the association between the A49P polymorphism of the TAS2R38 gene and chili consumption in Mexican adults.

Methods

A cross-sectional analytical study was conducted with 200 adults of both sexes, residents of Tijuana, Baja California, Mexico. A validated questionnaire was applied to assess chili consumption. Genotyping of the A49P polymorphism (TAS2R38) was performed using an allelic discrimination assay. Chi² tests and logistic regression were used.

Results

The frequency of allele A was 52.25% and allele P was 47.75%. A total of 10% individuals had genotype AA, 84.5% had AP, and 5.5% had PP. The 100% of individuals with genotype AA consumed chili, showing a statistically significant association (P = 0.024). Code ethic (D235, accepted on 22 October 2019).

Conclusions

The results show that chili consumption in the Mexican population is significantly associated with the A49P polymorphism of the TAS2R38 gene, reflecting the genetic influence on preference for spicy foods. This finding supports the use of genetic profiling as a tool for designing personalized nutrition strategies to improve dietary adherence, promote health, and contribute to the future prevention of diet-related diseases.

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A49P多态性（TAS2R38）与墨西哥成年人辣椒消费的关系

背景/目的自前西班牙时代以来，辣椒一直是墨西哥文化和饮食的独特组成部分。然而，辣椒和其他食物对健康的影响可能因个人耐受性而异，受包括遗传在内的各种因素的影响。本研究的目的是评估墨西哥成年人TAS2R38基因的A49P多态性与辣椒消费之间的关系。自前西班牙时代以来，辣椒一直是墨西哥文化和饮食的独特组成部分。然而，辣椒和其他食物对健康的影响可能因个人耐受性而异，受包括遗传在内的各种因素的影响。本研究的目的是评估墨西哥成年人TAS2R38基因的A49P多态性与辣椒消费之间的关系。方法对墨西哥下加利福尼亚州提华纳市200名成年男女进行横断面分析研究。采用一份有效的问卷来评估辣椒的消费量。采用等位基因鉴别法对A49P多态性（TAS2R38）进行基因分型。采用Chi2检验和logistic回归。一项横断面分析研究对墨西哥下加利福尼亚州提华纳的200名男女成年人进行了调查。采用一份有效的问卷来评估辣椒的消费量。采用等位基因鉴别法对A49P多态性（TAS2R38）进行基因分型。采用Chi2检验和logistic回归。结果等位基因A和P的频率分别为52.25%和47.75%。AA基因型个体占10%，AP基因型个体占84.5%，PP基因型个体占5.5%。AA基因型个体100%食用辣椒，二者相关性显著（P = 0.024）。道德规范（D235, 2019年10月22日接受）。等位基因A的频率为52.25%，P的频率为47.75%。AA基因型个体占10%，AP基因型个体占84.5%，PP基因型个体占5.5%。AA基因型个体100%食用辣椒，二者相关性显著（P = 0.024）。道德规范（D235, 2019年10月22日接受）。结论墨西哥人群的辣椒消费与TAS2R38基因的A49P多态性显著相关，反映了遗传对辛辣食物偏好的影响。这一发现支持使用基因图谱作为设计个性化营养策略的工具，以提高饮食依从性，促进健康，并有助于未来预防饮食相关疾病。结果表明，墨西哥人群的辣椒消费与TAS2R38基因的A49P多态性显著相关，反映了遗传对辛辣食物偏好的影响。这一发现支持使用基因图谱作为设计个性化营养策略的工具，以提高饮食依从性，促进健康，并有助于未来预防饮食相关疾病。

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来源期刊

CAHIERS DE NUTRITION ET DE DIETETIQUE NUTRITION & DIETETICS-

CiteScore

0.60

自引率

33.30%

发文量

审稿时长

65 days

期刊介绍： Les Cahiers de nutrition et de diététique sont le lieu de communication reconnu pour les médecins spécialistes de la nutrition, les diététiciens, les professionnels et les chercheurs de agro-alimentaire, les enseignants et les étudiants. Les Cahiers de nutrition et de diététique abordent les sujets se rapportant à la biologie générale, à la médecine et à la nutrition, aux aliments, aux comportements alimentaires, à la diététique pratique, ainsi que des thèmes variés : activité physique, apports nutritionnels conseillés, dénutrition, alcool, obésité de enfant, aliments à effet santé, plaisir alimentaire, restauration collective, goûters et collations, allergies alimentaires...