Nodular fasciitis of the oral cavity presenting with periodic fever: a case report and literature review.

Abstract

Nodular fasciitis (NF) is a benign myofibroblastic neoplasm rarely found in the oral cavity. It typically presents with regional pain, numbness or paresthesia. Due to its high mitotic rate, rapid growth and local invasiveness, NF is often misdiagnosed as a malignancy. We report a case of NF in the oral cavity of a 55-year-old male. Two weeks prior to admission, a rapidly growing swelling appeared in his right buccal area, accompanied by low-grade afternoon fever. Clinical examination revealed a 4×5 cm mulberry-like mass with a pedicle and mucosal ulceration. The mass enlarged rapidly post biopsy. Histopathological examination confirmed a diagnosis of NF. The patient underwent local resection, resulting in resolution of the fever. No recurrence was observed during a 3-month follow-up. This is the first reported case of NF associated with a periodic fever, which may improve understanding of NF's inflammatory nature and aid in differential diagnosis.