Safety Assessment of Mefepronic Acid in Sheep.

IF 2.1 3区农林科学 Q2 VETERINARY SCIENCES

Veterinary Medicine and Science Pub Date : 2026-09-01 DOI:10.1002/vms3.71236

Rahmi Canbar, Tugba Melike Parlak, Muhittin Uslu, Enver Yazar

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引用次数: 0

Abstract

Background: Mefepronic acid is used as a choleretic agent in different animal species. Although mefepronic acid is used extra-label in sheep, information on its safety in this species is limited. The aim of this study was to determine the effects of mefepronic acid on serum oxidative stress, lipid metabolism and organ function parameters in sheep.

Methods: Mefepronic acid was administered to 10 sheep at a dose of 10 mg/kg (intramuscular, once daily, 3 days). Blood samples were taken at 0 and at 24, 48 and 72 h. 8-OHdG, MDA, SOD, GPX, CAT, CK-MB isoenzyme, troponin I, serum ALP, AST, ALT, total bilirubin, BUN, creatinine, cholesterol, triglycerides, LDL and HDL levels were measured.

Results: Mefepronic acid administration resulted in a transient increase in 8-OHdG levels (p < 0.05) and a decrease in CAT levels (p < 0.05), a transient increase in CK-MB isoenzyme levels (p < 0.05), and a decrease in BUN, HDL and LDL levels (p < 0.05), but no effect on other parameters (p > 0.05).

Conclusion: Administration of mefepronic acid to sheep may cause transient changes in oxidative stress parameters and CK-MB isoenzyme levels. However, these changes were not associated with an increase in troponin I levels or clinically significant myocardial damage. Mefepronic acid did not cause clinically significant adverse effects on liver or kidney function parameters.

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来源期刊

Veterinary Medicine and Science Veterinary-General Veterinary

CiteScore

3.00

自引率

0.00%

发文量

296

期刊介绍： Veterinary Medicine and Science is the peer-reviewed journal for rapid dissemination of research in all areas of veterinary medicine and science. The journal aims to serve the research community by providing a vehicle for authors wishing to publish interesting and high quality work in both fundamental and clinical veterinary medicine and science. Veterinary Medicine and Science publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper. We aim to be a truly global forum for high-quality research in veterinary medicine and science, and believe that the best research should be published and made widely accessible as quickly as possible. Veterinary Medicine and Science publishes papers submitted directly to the journal and those referred from a select group of prestigious journals published by Wiley-Blackwell. Veterinary Medicine and Science is a Wiley Open Access journal, one of a new series of peer-reviewed titles publishing quality research with speed and efficiency. For further information visit the Wiley Open Access website.