Values of D-dimer, APTT, PT and INR in distinguishing between acute ischemic stroke patients with and without non-valvular atrial fibrillation.

IF 1.9 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2026-03-17 DOI:10.5937/jomb0-60388

Qing Du, Xiaohui Zhao, Haixia Song, Ju Jiang, Kaiming Zheng, Yuezhan Zhang

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引用次数: 0

Abstract

Background: Treatment strategies differ in acute ischemic stroke (AIS) patients with and without non-valvular atrial fibrillation (NVAF): AIS with NVAF requires anticoagulation (e.g. warfarin/direct oral anticoagulants) for secondary prevention, while AIS without NVAF relies on antiplatelet therapy (e.g. aspirin/clopidogrel). It remains unclear whether coagulation function indices can be used to distinguish between the two conditions.

Methods: In this retrospective study, AIS patients with NVAF (AIS with NVAF group, n=43) and without NVAF (AIS without NVAF group, n = 90) admitted to our hospital were enrolled for final analysis. The levels of coagulation function indices, including d-dimer (DD), activated partial thromboplastin time (APTT), prothrombin time (PT), international normalised ratio (INR), thrombin time (TT), and fibrinogen, were tested before or on admission and compared between the two groups.

Results: Compared with AIS without NVAF group, DD, PT, and INR were increased and APTT was decreased in AIS with NVAF group (P< 0.05), whereas, there were no significantly statistical differences of TT and fibrinogen (P> 0.05); next, the AUC in distinguishing between AIS with and without NVAF were 0.753, 0.761, 0.775, and 0.770 for DD, APTT, PT, and INR, respectively (P< 0.05).

Conclusions: DD, APTT, PT and INR demonstrated moderate diagnostic value (AUC 0.75-0.78) for distinguishing AIS with NVAF.

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d -二聚体、APTT、PT和INR在急性缺血性卒中伴非瓣膜性房颤患者中的鉴别价值

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.