DNA Damage in Placental and Fetal Cells in Rats with Perinatal Immune Activation.

IF 0.7 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-22 DOI:10.1007/s10517-026-06731-9

A K Zhanataev, E A Anisina, K L Pligina, A S Solomina, A D Durnev

引用次数: 0

Abstract

Nuclear and mitochondrial DNA damage in placental and fetal cells of rats was evaluated in a LPS-induced model of perinatal immune activation. Six hours after a single administration of LPS (0.2 mg/kg), an increase in nuclear DNA damage was observed in both placental and fetal cells. The most pronounced changes were detected in the fetal head region. After 24 h, damage to nuclear DNA was detected in placental cells and the trunk of the fetuses. High variability of this parameter was observed between the placental and fetal samples from the same animal and between different animals. No increase in nuclear DNA damage was revealed 3 h after LPS treatment. Mitochondrial DNA damage in the studied cells was detected after a 6-h exposure to LPS.

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围产期免疫激活大鼠胎盘和胎儿细胞DNA损伤

在lps诱导的围产期免疫激活模型中，对大鼠胎盘和胎儿细胞的核和线粒体DNA损伤进行了评估。单次给药（0.2 mg/kg） 6小时后，胎盘和胎儿细胞的核DNA损伤均有所增加。在胎儿头部区域检测到最明显的变化。24 h后，胎盘细胞和胎儿干核DNA均出现损伤。在同一动物的胎盘和胎儿样本之间以及不同动物之间观察到该参数的高度可变性。LPS处理3 h后核DNA损伤未见增加。暴露于LPS 6小时后检测所研究细胞的线粒体DNA损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.