Palladium(II) Complexes with Triphenylphosphine, Diphenyl-2-Pyridylphosphine, and the Dodecachloro-closo-Dodecaborate Anion

IF 1.5 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Russian Journal of Inorganic Chemistry Pub Date : 2026-09-24 DOI:10.1134/S0036023626601868

A. A. Lukoshkova, A. S. Kubasov, G. A. Buzanov, A. V. Golubev, A. Yu. Bykov, V. V. Avdeeva, N. V. Breslav, T. M. Buslaeva, K. Yu. Zhizhin, N. T. Kuznetsov

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Abstract

In this work, cationic palladium(II) complexes with triphenylphosphine (Ph₃P) and/or diphenyl-2-pyridylphosphine (PyPh₂P), stabilized by the dodecachloro-closo-dodecaborate anion [B₁₂Cl₁₂]^2–, were synthesized for the first time. The synthesis was carried out in acetonitrile using a stepwise method involving ligand metathesis in the Pd(II) coordination sphere to form [PdL₂Cl₂] complexes (where L is a monodentate ligand) followed by the removal of chloride ions using Ag₂[B₁₂Cl₁₂]. The structures of the resulting complexes [Pd(Ph₃P)(CH₃CN)₂Cl]₂[B₁₂Cl₁₂], [Pd(Ph₃P)₂(CH₃CN)₂][B₁₂Cl₁₂]·CH₃CN, [Pd(PyPh₂P)₂(CH₃CN)][B₁₂Cl₁₂]·3CH₃CN, and [Pd(Ph₃P)(PyPh₂P)Cl]₂[B₁₂Cl₁₂]·4CH₃CN were determined using X-ray diffraction and IR spectroscopy. Reaction schemes for complex formation were proposed, taking into account the reactant ratio and the trans-effect. The cytotoxicity of the synthesized compounds was investigated using MDCK cell cultures; the results showed moderate toxicity, which, combined with the inertness of the boron cluster anion, opens up prospects for developing new palladium-based radioprotective agents.

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钯（II）与三苯基膦、二苯基-2-吡啶膦和十二氯-近十二硼酸阴离子的配合物

本文首次合成了以十二氯-近十二硼酸盐[B12Cl12]2 -为稳定离子的三苯基膦（Ph3P）和/或二苯基-2-吡啶膦（PyPh2P）阳离子钯（II）配合物。合成过程在乙腈中进行，采用配体在Pd（II）配位球中逐步复分解形成[PdL2Cl2]配合物（其中L是单齿配体），然后用Ag2[B12Cl12]去除氯离子。用x射线衍射和红外光谱测定了合成的配合物[Pd(Ph3P)(CH3CN)2Cl]2[B12Cl12]、[Pd(Ph3P)2(CH3CN)2][B12Cl12]·CH3CN、[Pd(PyPh2P)2(CH3CN)][B12Cl12]·3CH3CN和[Pd(Ph3P)(PyPh2P)Cl]2[B12Cl12]·4CH3CN的结构。提出了考虑反应物比和反式效应的络合物生成反应方案。利用MDCK细胞培养研究了合成化合物的细胞毒性；结果表明，该化合物毒性适中，且硼簇阴离子具有惰性，为开发新型钯基放射防护剂开辟了广阔的前景。

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来源期刊

Russian Journal of Inorganic Chemistry 化学-无机化学与核化学

CiteScore

3.10

自引率

38.10%

发文量

237

审稿时长

3 months

期刊介绍： Russian Journal of Inorganic Chemistry is a monthly periodical that covers the following topics of research: the synthesis and properties of inorganic compounds, coordination compounds, physicochemical analysis of inorganic systems, theoretical inorganic chemistry, physical methods of investigation, chemistry of solutions, inorganic materials, and nanomaterials.