Preparation of multifunctional protein-capped selenium nanoparticles for drug delivery

IF 1.7 3区化学 Q3 CHEMISTRY, ANALYTICAL

Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2026-09-09 DOI:10.1007/s10967-026-11103-8

Amna Saeed, Aisha Munawar, Irfan Ullah Khan, Rizwana Zahoor, Arjumand Iqbal Durrani, Muhammad Waqas Ishaq, Surriya Bibi

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Abstract

This study focuses on the development of drug-loaded and radiolabeled nanoparticles with high carrying capacity for applications in diagnostic imaging and chemotherapy. Stable selenium nanoparticles (SeNPs) with controlled size were synthesized through a redox reaction involving ascorbic acid and sodium selenite. Doxorubicin (DOX) was efficiently loaded onto bromelain-capped SeNPs (BR-SeNPs), achieving a loading efficiency of 86.7%. The morphology and physicochemical properties of BR-SeNPs and DOX-BR-SeNPs were characterized using UV–visible spectrophotometry, dynamic light scattering (DLS), Fourier transform infrared (FTIR) spectroscopy, and zeta potential analysis. Radiolabeling of DOX-BR-SeNPs with ⁹⁹ᵐTc yielded an efficiency of ≥91 ± 2%. SPECT imaging in an animal model revealed considerable uptake in the liver, heart, and bladder. Collectively, these findings demonstrate that DOX-BR-SeNPs constitute a promising nanocarrier system for both diagnostic imaging and targeted drug delivery.

Graphical abstract

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用于药物递送的多功能蛋白包盖硒纳米颗粒的制备

本研究的重点是开发具有高承载能力的载药和放射性标记纳米颗粒，用于诊断成像和化疗。以抗坏血酸和亚硒酸钠为原料，通过氧化还原反应合成了粒径可控的稳定硒纳米粒子。将多柔比星（DOX）高效加载到菠萝蛋白酶盖顶的SeNPs （BR-SeNPs）上，加载效率为86.7%。采用紫外可见分光光度法、动态光散射（DLS）、傅立叶变换红外光谱（FTIR）和zeta电位分析对BR-SeNPs和DOX-BR-SeNPs的形貌和理化性质进行了表征。对DOX-BR-SeNPs的放射性标记效率为≥91±2%。动物模型的SPECT成像显示肝脏、心脏和膀胱有大量摄取。总的来说，这些发现表明，DOX-BR-SeNPs是一种很有前途的纳米载体系统，可用于诊断成像和靶向药物递送。图形抽象

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来源期刊

Journal of Radioanalytical and Nuclear Chemistry 化学-分析化学

CiteScore

2.80

自引率

18.80%

发文量

504

审稿时长

2.2 months

期刊介绍： An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.