Lysosomes enlist endoplasmic reticulum microdomains for repair

IF 22.7 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2026-09-23 DOI:10.1038/s41556-026-02064-x

Zhengyang An, Song Dang, Kangmin He

引用次数: 0

Abstract

Maintaining lysosomal membrane integrity is essential for lysosomal function and cellular homeostasis. A study now describes a lysosome repair mechanism, in which phosphatidylinositol 3-phosphate and DFCP1 accumulation at endoplasmic reticulum (ER) microdomains drives focal enrichment of the lipid channel protein VPS13C at ER–lysosome contact sites to promote lysosomal repair.

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溶酶体利用内质网微域进行修复

维持溶酶体膜的完整性对溶酶体功能和细胞稳态至关重要。一项研究描述了溶酶体修复机制，其中磷脂酰肌醇3-磷酸和DFCP1在内质网（ER）微域的积累驱动内质网溶酶体接触位点的脂质通道蛋白VPS13C的局部富集，从而促进溶酶体修复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology