A pilot study investigating the effect of serum 25-hydroxyvitamin D on device-estimated sleep metrics in young black women: a single-arm open-label clinical trial.
Michele N D'Agata, Krista M Szymanski, Freda Patterson, Mackenzie L Rattigan, Alexs A Matias, David G Edwards, Christopher R Martens, Sushant M Ranadive, Melissa A Witman
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Abstract
Study objectives: Vitamin D deficiency has been linked to poor sleep health outcomes in the general population. Black women (BLW) experience a higher prevalence of vitamin D deficiency and short and disturbed sleep compared with other races. Therefore, this study tested cross-sectional associations between serum 25-hydroxyvitamin D concentration ([25(OH)D]) and sleep health estimates in young adult BLW, followed by an 8-week vitamin D supplementation intervention.
Materials and methods: Forty-three 18-30-year-old BLW underwent blood sampling for serum [25(OH)D]. Sleep metrics were derived from 14-days of wrist accelerometry. Thereafter, participants with [25(OH)D] <30 ng/ml (N = 16) completed an 8-week vitamin D3 supplementation intervention (5000 IU/day) and repeated blood sampling and sleep monitoring.
Results: Linear regressions demonstrate significant cross-sectional associations for [25(OH)D] with sleep efficiency (β = 0.11, p = .03; %) and sleep onset standard deviation (SOSD) (β = -0.53, p = .04; minutes), but no associations with sleep duration or sleep duration standard deviation (p > .18). Among intervention participants, paired-sample t-tests demonstrate a significant increase in [25(OH)D] (16.8 ± 7.0 vs. 55.3 ± 10.0, ng/ml; p < .001), however, no changes were observed among actigraphy-derived sleep variables (all p > .21).
Conclusions: [25(OH)D] was cross-sectionally associated with sleep efficiency and SOSD, however, intervention results from this pilot study do not demonstrate a beneficial effect of vitamin D on several device-estimated sleep metrics in young BLW.
Clinical trial registration: Effects of Vitamin D on Cardiovascular Health in Black Women, https://clinicaltrials.gov/study/NCT05656742?locStr=Delaware&country=United%20States&state=Delaware&cond=Vitamin%20D%20Deficiency&term=blood%20pressure&intr=Vitamin%20D&rank=1 Registered on ClinicalTrials.gov ID NCT05656742.
研究目标：在普通人群中，维生素D缺乏与睡眠健康状况不佳有关。与其他种族相比，黑人女性（BLW）的维生素D缺乏症和睡眠不足的患病率更高。因此，本研究测试了年轻成年BLW患者血清25-羟基维生素D浓度（[25(OH)D]）与睡眠健康评估之间的横断面关联，随后进行了为期8周的维生素D补充干预。材料与方法：对43例18-30岁BLW进行血清[25(OH)D]采血。睡眠指标来自14天的手腕加速度计。结果：线性回归显示[25(OH)D]与睡眠效率（β = 0.11, p = 0.03; %）和睡眠开始标准偏差（SOSD） （β = -0.53, p = 0.04；分钟）有显著的横断面关联，但与睡眠持续时间或睡眠持续时间标准偏差（p >.18）没有关联。在干预参与者中，配对样本t检验显示[25(OH)D]显著增加（16.8±7.0 vs. 55.3±10.0,ng/ml; p p >.21）。结论：[25(OH)D]与睡眠效率和SOSD横断面相关，然而，本初步研究的干预结果并未证明维生素D对年轻BLW中几个设备估计的睡眠指标有有益影响。临床试验注册：维生素D对黑人妇女心血管健康的影响，https://clinicaltrials.gov/study/NCT05656742?locStr=Delaware&country=United%20States&state=Delaware&cond=Vitamin%20D%20Deficiency&term=blood%20pressure&intr=Vitamin%20D&rank=1在ClinicalTrials.gov注册ID NCT05656742。
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