Clinical Conditions Associated With Elevated Lactate Levels in Hospitalized Children.

IF 1.8 4区医学 Q1 PEDIATRICS

Acta Paediatrica Pub Date : 2026-09-22 DOI:10.1111/apa.70780

Eveliina Kuitunen, Ilari Kuitunen, Miika Arvonen, Marjo Renko

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引用次数: 0

Abstract

Aim: Lactate is included in adult septic shock criteria, but its role in paediatric sepsis is unclear. Recent guidelines propose lactate thresholds, though supporting evidence is limited. We aimed to identify conditions associated with elevated lactate in children and determine where levels are highest.

Methods: We conducted a 10-year retrospective cohort study of patients < 17 years admitted to ICU or acute paediatric wards (2013-2023). Patients with elevated lactate were included. Diagnoses were grouped into 11 categories and underlying conditions into five groups. Maximum lactate levels were compared across diagnostic categories.

Results: Among 3039 patients (4577 hospitalisations), 175 had lactate ≥ 5 mmol/L. Respiratory infections were most common (45.1%), while sepsis/meningitis accounted for 4%. Median lactate was highest in sepsis/meningitis, exceeding six other categories. Only five patients had lactate ≥ 11 mmol/L, mostly with sepsis/meningitis.

Conclusions: Elevated lactate is common in hospitalised children and occurs across diverse conditions. Although highest in sepsis, most cases are non-septic. Lactate should be interpreted in a clinical context.

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住院儿童乳酸水平升高的临床状况

目的：乳酸被纳入成人感染性休克标准，但其在儿科败血症中的作用尚不清楚。最近的指南建议乳酸阈值，尽管支持证据有限。我们的目的是确定与儿童乳酸水平升高相关的条件，并确定哪里的乳酸水平最高。方法：我们对患者进行了一项为期10年的回顾性队列研究。结果：在3039例患者（4577例住院）中，175例乳酸≥5 mmol/L。呼吸道感染最为常见（45.1%），败血症/脑膜炎占4%。乳酸中位数在败血症/脑膜炎中最高，超过其他6个类别。仅有5例患者乳酸≥11mmol /L，多为脓毒症/脑膜炎。结论：乳酸水平升高在住院儿童中很常见，发生在多种情况下。虽然在脓毒症中发病率最高，但大多数病例是非脓毒症。乳酸应该在临床背景下解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Paediatrica 医学-小儿科

CiteScore

6.50

自引率

5.30%

发文量

384

审稿时长

2-4 weeks

期刊介绍： Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including: neonatal medicine developmental medicine adolescent medicine child health and environment psychosomatic pediatrics child health in developing countries