High-Resolution Optical Coherence Tomography Visualizes Posterior Vitreous Lamellar Architecture in Eyes With Chronic Central Serous Chorioretinopathy.

IF 2.7 3区医学 Q2 OPHTHALMOLOGY

Translational Vision Science & Technology Pub Date : 2026-09-01 DOI:10.1167/tvst.15.9.14

Yoko Miura, Dinh Nho Vu, Joyce Tohme, Ophir Reinhardt, Giorgio Bozzini, Svenja Rebecca Sonntag, Salvatore Grisanti

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引用次数: 0

Abstract

Purpose: High-resolution optical coherence tomography (HighRes-OCT) enables in vivo visualization of microstructural features that are not accessible with conventional clinical OCT systems. Using this capability, we investigated posterior vitreous microarchitecture in eyes with chronic central serous chorioretinopathy (CSC) and healthy individuals.

Methods: HighRes-OCT imaging (axial resolution approximately 3 µm) was performed in 20 patients with chronic CSC and 20 age-matched healthy subjects. Posterior vitreous structures were qualitatively assessed for the presence of discrete lamellar patterns and compared with conventional spectral-domain OCT (SD-OCT) acquired at the same visits. Lamellar visibility was evaluated across scan orientations, and reproducibility was assessed in all CSC eyes with follow-up imaging.

Results: Distinct hyper-reflective lamellar structures within the posterior vitreous were clearly identified in 9 of 20 CSC eyes, whereas no comparable lamellar organization was observed in healthy eyes. In CSC eyes, lamellae appeared as parallel, layered bands located immediately anterior to the internal limiting membrane and were reproducible across scan orientations. These structures were not readily discernible on conventional OCT. Healthy eyes showed relatively homogeneous vitreous reflectivity, although faint linear structures were occasionally observed.

Conclusions: HighRes-OCT enables in vivo visualization of posterior vitreous lamellar microstructures that are not readily discernible with conventional clinical OCT. The preferential detection of these structures in eyes with chronic CSC suggests disease-associated alterations in vitreous matrix organization and highlights a previously underexplored dimension of vitreous imaging.

Translational relevance: Visualization of vitreous microarchitecture using HighRes-OCT may provide a new translational imaging window to study disease-related vitreous remodeling and its relationship to retinal pathology.

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高分辨率光学相干断层扫描显示慢性中枢性浆液性脉络膜视网膜病变的眼后玻璃体板层结构。

目的：高分辨率光学相干断层扫描（HighRes-OCT）能够实现常规临床OCT系统无法实现的显微结构特征的体内可视化。利用这种能力，我们研究了慢性中枢性浆液性脉络膜视网膜病变（CSC）和健康人的眼后玻璃体微结构。方法：对20例慢性CSC患者和20例年龄匹配的健康受试者进行高分辨率oct成像（轴向分辨率约为3µm）。对后玻璃体结构进行定性评估，以确定是否存在离散的板层模式，并与同一次就诊时获得的常规光谱域OCT （SD-OCT）进行比较。通过随访成像评估所有CSC眼的片层可见性和再现性。结果：20只CSC眼中有9只在后玻璃体内清晰地发现了明显的超反射板层结构，而在健康眼中没有观察到类似的板层组织。在CSC眼中，片层呈平行层状，位于内限制膜前方，并且在整个扫描方向上可重复。正常眼睛的玻璃体反射率相对均匀，偶尔可见微弱的线性结构。结论：HighRes-OCT能够实现常规临床oct难以识别的后玻璃体板层显微结构的活体可视化。在慢性CSC患者的眼睛中优先检测到这些结构，表明玻璃体基质组织的疾病相关改变，并突出了以前未被探索的玻璃体成像维度。翻译相关性：使用HighRes-OCT可视化玻璃体微结构可能为研究疾病相关玻璃体重塑及其与视网膜病理的关系提供新的翻译成像窗口。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Vision Science & Technology Engineering-Biomedical Engineering

CiteScore

5.70

自引率

3.30%

发文量

346

审稿时长

25 weeks

期刊介绍： Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO. The journal covers a broad spectrum of work, including but not limited to: Applications of stem cell technology for regenerative medicine, Development of new animal models of human diseases, Tissue bioengineering, Chemical engineering to improve virus-based gene delivery, Nanotechnology for drug delivery, Design and synthesis of artificial extracellular matrices, Development of a true microsurgical operating environment, Refining data analysis algorithms to improve in vivo imaging technology, Results of Phase 1 clinical trials, Reverse translational ("bedside to bench") research. TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.