Bryce B Reeve, Li Lin, Brian Thorsen, Rachel Gomel, Christopher L Bowlus, Donna M Evon
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引用次数: 0
Abstract
Purpose: The study goal is to evaluate the psychometric properties of Patient-Reported Outcomes Measurement Information System® (PROMIS®) Fatigue and Cognitive Function Short Forms customized for use in adults with primary sclerosing cholangitis (PSC).
Methods: Participants completed a survey through the PSC Partners Patient Registry. The survey included the customized PROMIS short forms, the PROMIS Global Health scale, the PROMIS Sleep-related Impairment short form, and self-reported sociodemographic and clinical data. The factor structure was evaluated with confirmatory factor analysis, and reliability indices included coefficient alpha for internal consistency and intra-class correlations for test-retest reliability. Construct validity was evaluated based on the associations of the customized short forms with related patient-reported outcomes and the ability to differentiate between known groups.
Results: Participants included 287 adults, including 55% female, 93% White race, with a mean age of 52 years. Both Fatigue and Cognitive Function short forms were confirmed to be unidimensional, with internal consistency reliability of 0.98 and 0.97, and test-retest reliability of 0.92 and 0.89, respectively. The correlation between Fatigue and Cognitive Function scores was - 0.76, and had strong associations with physical health, mental health, sleep-related impairment, work productivity, and daily activities. Both customized short forms found statistically significantly worse fatigue and cognitive functioning in women, those with cirrhosis, and with a hepatic decompensation event in the past 12 months.
Conclusion: This study provided strong evidence for the construct validity and reliability of the PROMIS Fatigue and Cognitive Function short forms customized for adults with PSC. These PSC-specific outcome measures will benefit clinical research.
期刊介绍：
Quality of Life Research is an international, multidisciplinary journal devoted to the rapid communication of original research, theoretical articles and methodological reports related to the field of quality of life, in all the health sciences. The journal also offers editorials, literature, book and software reviews, correspondence and abstracts of conferences.
Quality of life has become a prominent issue in biometry, philosophy, social science, clinical medicine, health services and outcomes research. The journal''s scope reflects the wide application of quality of life assessment and research in the biological and social sciences. All original work is subject to peer review for originality, scientific quality and relevance to a broad readership.
This is an official journal of the International Society of Quality of Life Research.
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