L Gassiat, I Gauthereau, G Cardouat, P Robillard, C M Pilard, B Pere, E Dumas-De-La-Roque, F Sauvestre, F Pelluard, S Berenguer, L Sentilhes, F Coatleven, M Vincienne, P Berger, C Guibert
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引用次数: 0
Abstract
Bronchopulmonary dysplasia (BPD) is the most common chronic respiratory disease in premature newborns born before 32 weeks of gestation. It is characterized by arrested lung growth (hypoalveolarization), rarefaction of microvascularisation (hypoangiogenesis), and inflammation. BPD can be complicated by pulmonary hypertension (PH-BPD), which increases the mortality rate by nearly 50% within two years after diagnosis. Thrombomodulin is a glycoprotein mainly expressed on vascular endothelial cells. It plays a central role in hemostasis, but also contributes to inflammation and angiogenesis and is used as a biomarker in certain cardiopulmonary pathologies. Deregulation of its expression may therefore play an important role in the development of inflammatory diseases and/or angiogenesis defects, such as PH-BPD.
期刊介绍：
La Revue des Maladies Respiratoires est l''organe officiel d''expression scientifique de la Société de Pneumologie de Langue Française (SPLF). Il s''agit d''un média professionnel francophone, à vocation internationale et accessible ici.
La Revue des Maladies Respiratoires est un outil de formation professionnelle post-universitaire pour l''ensemble de la communauté pneumologique francophone. Elle publie sur son site différentes variétés d''articles scientifiques concernant la Pneumologie :
- Editoriaux,
- Articles originaux,
- Revues générales,
- Articles de synthèses,
- Recommandations d''experts et textes de consensus,
- Séries thématiques,
- Cas cliniques,
- Articles « images et diagnostics »,
- Fiches techniques,
- Lettres à la rédaction.
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