Boundary-anchored thalamic ADC profiling shows spatially structured abnormalities in multiple sclerosis.

IF 2 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Rofo-fortschritte Auf Dem Gebiet Der Rontgenstrahlen Und Der Bildgebenden Verfahren Pub Date : 2026-09-21 DOI:10.1055/a-2941-6690

Malvina Garner, Frederik Fries, Christoph Garner, Alena Haußmann, Wolfgang Reith, Umut Yilmaz

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引用次数: 0

Abstract

Purpose: Diffusion MRI is sensitive to tissue abnormalities in multiple sclerosis (MS), but conventional region-of-interest measures reduce spatially structured signal patterns to a single summary value. We evaluated boundary-anchored thalamic apparent diffusion coefficient (ADC) profiling in MS using line-based edge-anchored profiling (LEAP).

Materials and methods: In this retrospective matched-control study, age- and sex-matched controls (CTRL, n = 28) and participants with relapsing-remitting MS (RRMS, n = 14) or secondary progressive MS (SPMS, n = 14) were analyzed on the same 3T MRI scanner using the same diffusion protocol. LEAP was applied bilaterally at the medial thalamic surface adjacent to the third ventricle. Participant-averaged bilateral summary metrics and exploratory side-specific profile-shape metrics were derived from ADC curves.

Results: The clearest signal was observed in comparisons between MS and matched controls, with the largest number of differences seen for SPMS versus controls. Compared with controls, SPMS showed a higher ventricle-near mean ADC (p = 0.004), higher profile maximum ADC (p = 0.003), and a steeper early profile slope (p = 0.005). RRMS generally showed intermediate values. Direct RRMS-versus-SPMS comparisons of bilateral summary metrics were limited. Exploratory right-sided profile-shape metrics and left-right asymmetry measures suggested possible phenotype-related differences.

Conclusion: Boundary-anchored thalamic ADC profiling detected spatially structured abnormalities in MS relative to matched controls, with the strongest deviation in SPMS. Exploratory shape-based findings should be considered hypothesis-generating and suggest additional profile-level information beyond bilateral summary values.

Key points: · LEAP enables spatially resolved thalamic ADC assessment.. · SPMS showed strongest deviations from matched controls.. · RRMS demonstrated intermediate profile characteristics.. · Profile morphology contained information beyond bilateral averages.. · Boundary-anchored profiling complements conventional ROI analysis..

Citation format: · Garner M, Fries F, Garner C et al. Boundary-anchored thalamic ADC profiling shows spatially structured abnormalities in multiple sclerosis. Rofo 2026; DOI 10.1055/a-2941-6690.

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边界锚定丘脑ADC谱显示多发性硬化症的空间结构异常。

目的：扩散MRI对多发性硬化症（MS）的组织异常敏感，但传统的感兴趣区域测量将空间结构信号模式降低到单一的汇总值。我们使用基于线的边缘锚定谱（LEAP）来评估MS中边界锚定的丘脑表观扩散系数（ADC）谱。材料和方法：在这项回顾性匹配对照研究中，年龄和性别匹配的对照组（CTRL, n = 28）和复发缓解型多发性硬化症（RRMS, n = 14）或继发性进展型多发性硬化症（SPMS, n = 14）在相同的3T MRI扫描仪上使用相同的扩散方案进行分析。LEAP应用于双侧靠近第三脑室的丘脑内侧表面。参与者平均双侧总结指标和探索性侧面特定轮廓形状指标来自ADC曲线。结果：在MS和匹配对照之间的比较中观察到最清晰的信号，SPMS与对照之间的差异最大。与对照组相比，SPMS表现出更高的心室附近平均ADC (p = 0.004)，更高的轮廓最大ADC （p = 0.003）和更陡峭的早期轮廓斜率（p = 0.005）。RRMS一般表现为中间值。双边汇总指标的直接rrms与spms比较是有限的。探索性右侧轮廓形状测量和左右不对称测量表明可能的表型相关差异。结论：边界锚定丘脑ADC谱检测到MS相对于匹配对照组的空间结构异常，SPMS偏差最大。探索性的基于形状的发现应该被认为是假设的产生，并建议在双边总结值之外提供额外的概况级别信息。·LEAP实现了空间分辨的丘脑ADC评估。·SPMS与匹配对照的偏差最大。·RRMS具有中间剖面特征。·剖面形态包含了双边平均值之外的信息。·边界锚定分析补充了传统的ROI分析。引文格式：·Garner M， Fries F， Garner C等。边界锚定丘脑ADC谱显示多发性硬化症的空间结构异常。Rofo 2026;DOI 10.1055 / - 2941 - 6690。

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来源期刊

Rofo-fortschritte Auf Dem Gebiet Der Rontgenstrahlen Und Der Bildgebenden Verfahren 医学-核医学

CiteScore

1.20

自引率

5.60%

发文量

340

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