Plant-Derived Extracellular Vesicles: Biogenesis, Function, and Application in Cancer Immunotherapy.

IF 8.1 2区医学 Q1 CHEMISTRY, MEDICINAL

Phytotherapy Research Pub Date : 2026-09-21 DOI:10.1002/ptr.70456

Guosheng Li, Mengyu Li, Shujing Liu, Yuan Wei, Chen Wang

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引用次数: 0

Abstract

Plant-derived extracellular vesicles (PDEVs) are nanoscale, lipid bilayer-enclosed vesicles secreted by plant cells. They are widely distributed across plant tissues, including fruits, roots, stems, and leaves, and are particularly abundant in edible and medicinal plant species. This review presents a comprehensive overview of recent advances in PDEV research, focusing on their biogenesis, isolation strategies, physicochemical characterization, and cross-kingdom regulatory mechanisms. We highlight the multifaceted roles of PDEVs in anti-tumor immunity, including tumor cell suppression, immune stimulation, drug delivery, and gut-microbiota-mediated immunomodulation. Despite their therapeutic potential, challenges remain in standardization and pharmacokinetic profiling. Emerging engineering strategies offer promising solutions to improve targeting and therapeutic efficacy. Additionally, PDEVs provide a unique platform for mechanistic exploration of traditional Chinese medicine. By integrating current knowledge and future perspectives, this review aims to advance the translational application of PDEVs in cancer immunotherapy and dietary intervention.

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植物源性细胞外囊泡：生物发生、功能及其在癌症免疫治疗中的应用。

植物源性细胞外囊泡（PDEVs）是由植物细胞分泌的纳米级脂质双分子层封闭囊泡。它们广泛分布在植物组织中，包括果实、根、茎和叶，在食用和药用植物物种中尤其丰富。本文综述了近年来PDEV的研究进展，重点介绍了它们的生物发生、分离策略、理化特性和跨界调控机制。我们强调PDEVs在抗肿瘤免疫中的多方面作用，包括肿瘤细胞抑制、免疫刺激、药物传递和肠道微生物介导的免疫调节。尽管它们具有治疗潜力，但在标准化和药代动力学分析方面仍存在挑战。新兴的工程策略为提高靶向性和治疗效果提供了有希望的解决方案。此外，PDEVs为中医的机械探索提供了一个独特的平台。通过整合现有知识和未来观点，本文旨在推进PDEVs在癌症免疫治疗和饮食干预中的转化应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytotherapy Research 医学-药学

CiteScore

12.80

自引率

5.60%

发文量

325

审稿时长

2.6 months

期刊介绍： Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.