The causes of cachexia: key signals and the brain.

IF 39.1 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature Reviews Endocrinology Pub Date : 2026-09-21 DOI:10.1038/s41574-026-01302-4

Aideen Daly, Su Lei Yin, Anthony P Coll

引用次数: 0

Abstract

Cachexia is a multisystem, complex disorder of body weight and body composition characterized by a relentless, non-resolving wasting of metabolic reserve that, although long recognized and described, continues to elude effective treatment. A continued focus on central nervous system pathways as key drivers of some of the cardinal features of cachexia now points towards the development of long-needed effective interventions. In this Review, we focus on several key signals, namely growth differentiation factor 15, melanocortins and interleukin-6, that illustrate the power of cross-disciplinary thinking to better understand how humoral signals affect body composition, behaviour and cognition in cachexia.

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恶病质的成因：关键信号与大脑。

恶病质是一种多系统、复杂的体重和身体组成紊乱，其特征是代谢储备的持续、不可解决的浪费，尽管长期以来被认识和描述，但仍然缺乏有效的治疗。持续关注中枢神经系统通路作为恶病质一些主要特征的关键驱动因素，现在指向长期需要的有效干预措施的发展。在这篇综述中，我们将重点关注几个关键信号，即生长分化因子15、黑素皮质素和白介素-6，这些信号说明了跨学科思维的力量，以更好地理解体液信号如何影响恶病质中的身体成分、行为和认知。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Endocrinology 医学-内分泌学与代谢

CiteScore

42.00

自引率

0.70%

发文量

158

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Endocrinology aspires to be the foremost platform for reviews and commentaries catering to the scientific communities it serves. The journal aims to publish articles characterized by authority, accessibility, and clarity, enhanced with easily understandable figures, tables, and other visual aids. The goal is to offer an unparalleled service to authors, referees, and readers, striving to maximize the usefulness and impact of each article. Nature Reviews Endocrinology publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians in the fields of endocrinology and metabolism. Its broad scope ensures that the work it publishes reaches the widest possible audience.