P W Kronen, B D X Lascelles, B P Monteiro, J C Murrell, S A Robertson, P V Steagall, B Wright
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引用次数: 0
Abstract
This is a mini review published by the World Small Animal Veterinary Association's Pain Committee. This article provides an assessment of the scientific evidence of N-methyl-d-aspartate receptor antagonists for controlling pain in dogs while identifying current knowledge gaps. The pathophysiology of chronic pain related to the N-methyl-d-aspartate receptor is reviewed, followed by the clinical application of some drugs in this class in clinical practice, with suggested dosage regimens. N-methyl-D-aspartate receptor antagonists are an attractive group of drugs to manage long-standing pain because of the pivotal role of the N-methyl-d-aspartate receptor in central sensitisation and upregulation of pain pathways. More studies are needed to support the use of these drugs perioperatively and for treatment of chronic pain. Currently, information on best dosage regimens, safety, efficacy and which painful conditions can be targeted is lacking.
期刊介绍：
Journal of Small Animal Practice (JSAP) is a monthly peer-reviewed publication integrating clinical research papers and case reports from international sources, covering all aspects of medicine and surgery relating to dogs, cats and other small animals. These papers facilitate the dissemination and implementation of new ideas and techniques relating to clinical veterinary practice, with the ultimate aim of promoting best practice. JSAP publishes high quality original articles, as well as other scientific and educational information. New developments are placed in perspective, encompassing new concepts and peer commentary. The target audience is veterinarians primarily engaged in the practise of small animal medicine and surgery.
In addition to original articles, JSAP will publish invited editorials (relating to a manuscript in the same issue or a topic of current interest), review articles, which provide in-depth discussion of important clinical issues, and other scientific and educational information from around the world.
The final decision on publication of a manuscript rests with the Editorial Board and ultimately with the Editor. All papers, regardless of type, represent the opinion of the authors and not necessarily that of the Editor, the Association or the Publisher.
The Journal of Small Animal Practice is published on behalf of the British Small Animal Veterinary Association and is also the official scientific journal of the World Small Animal Veterinary Association
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