Predicting risk of infection in infants with gastroschisis.

IF 2.3 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2026-09-21 DOI:10.1038/s41372-026-02880-x

Stefanie Riddle, Isabella Zaniletti, Karna Murthy, Alaina Pyle, Ellen Bendel-Stenzel, Elizabeth Jacobson, Theresa Grover, Heidi Karpen, Franscesca Miquel-Verges, Sadie Williams, Jennifer Rumpel, Michael A Padula

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引用次数: 0

Abstract

Objective: Identify clinical predictors of bloodstream (BSI) and urinary tract infections (UTI) in infants with gastroschisis.

Study design: Retrospective analysis of infants with gastroschisis admitted to 47 neonatal intensive care units (NICUs) contributing to the Children's Hospitals Neonatal Database (CHND) from 2010-23. Outcomes were occurrence of BSI or UTI before discharge. Generalized linear models with generalized estimating equation (GEE) to account for hospitals as clusters utilized to identify factors independently related to the outcomes.

Result: Of 3987 eligible infants, rates of early BSI (within 3 days of birth) were 0.4%, any BSI 7.6% and UTI 3.5%. Median age of infection was 32 days for BSI and 39 days for UTI. Bowel atresia, silo/staged closure, patch closure, and additional anomalies were independently associated with these infections.

Conclusion: We identified clinical predictors of BSI and UTI, which should facilitate limitation of antibiotic use in low risk patients.

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预测腹裂婴儿感染的风险。

目的：探讨胃裂患儿血流（BSI）和尿路感染（UTI）的临床预测因素。研究设计：回顾性分析2010-23年儿童医院新生儿数据库（CHND）中47个新生儿重症监护病房（NICUs）收治的胃裂婴儿。结果为出院前出现BSI或UTI。使用广义估计方程（GEE）的广义线性模型来解释医院作为集群，用于识别与结果独立相关的因素。结果：在3987名符合条件的婴儿中，早期BSI（出生3天内）的发生率为0.4%，任何BSI为7.6%，UTI为3.5%。BSI的中位感染年龄为32天，UTI的中位感染年龄为39天。肠闭锁、筒仓/分阶段封闭、补片封闭和其他异常与这些感染独立相关。结论：我们确定了BSI和UTI的临床预测因素，这将有助于限制低危患者抗生素的使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.