Pravin M, Ambalakkuthan Murugesan, Usha Devi R, Nishad Plakkal
{"title":"Safety and Tolerability of Early Minimal Enteral Nutrition from Birth in Preterm Neonates with Antenatal Doppler Abnormalities.","authors":"Pravin M, Ambalakkuthan Murugesan, Usha Devi R, Nishad Plakkal","doi":"10.1007/s12098-026-06411-6","DOIUrl":null,"url":null,"abstract":"<p><p>Small-for-gestational-age neonates with absent / reversal of end diastolic flow (AREDF) in umbilical artery doppler are at increased risk of perinatal complications. The authors conducted a retrospective cohort study in SGA neonates (≤34 wk) with AREDF to study the tolerability of early minimal enteral nutrition (MEN) initiated from birth, and compared the outcomes with those without AREDF. Out of 207 SGA neonates, 82 had AREDF. AREDF group had a significantly lower mean birth weight (1185 g vs. 1368 g; p <0.001) and a higher incidence of birth by caesarean section (85.4% vs. 60.8%, p < 0.0001). There was no difference in the primary outcome of feed intolerance [20.7% vs. 12.8%; RR 1.62 (0.87-3.02)]. Mortality, necrotizing enterocolitis (NEC), culture-proven sepsis were also similar between the groups. Multivariable logistic regression analysis revealed that gestational age and not AREDF status was associated with increased odds of feed intolerance.</p>","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"1212-1214"},"PeriodicalIF":2.4000,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Pediatrics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12098-026-06411-6","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/9/21 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0
Abstract
Small-for-gestational-age neonates with absent / reversal of end diastolic flow (AREDF) in umbilical artery doppler are at increased risk of perinatal complications. The authors conducted a retrospective cohort study in SGA neonates (≤34 wk) with AREDF to study the tolerability of early minimal enteral nutrition (MEN) initiated from birth, and compared the outcomes with those without AREDF. Out of 207 SGA neonates, 82 had AREDF. AREDF group had a significantly lower mean birth weight (1185 g vs. 1368 g; p <0.001) and a higher incidence of birth by caesarean section (85.4% vs. 60.8%, p < 0.0001). There was no difference in the primary outcome of feed intolerance [20.7% vs. 12.8%; RR 1.62 (0.87-3.02)]. Mortality, necrotizing enterocolitis (NEC), culture-proven sepsis were also similar between the groups. Multivariable logistic regression analysis revealed that gestational age and not AREDF status was associated with increased odds of feed intolerance.
脐动脉多普勒舒张末期血流（AREDF）缺失/逆转的小胎龄新生儿围产期并发症风险增加。作者对接受AREDF治疗的SGA新生儿（≤34周）进行了回顾性队列研究，以研究从出生开始的早期最小肠内营养（MEN）的耐受性，并将结果与未接受AREDF治疗的新生儿进行了比较。在207名SGA新生儿中，82名患有AREDF。AREDF组新生儿平均出生体重显著低于对照组（1185 g vs 1368 g）
期刊介绍：
Indian Journal of Pediatrics (IJP), is an official publication of the Dr. K.C. Chaudhuri Foundation. The Journal, a peer-reviewed publication, is published twelve times a year on a monthly basis (January, February, March, April, May, June, July, August, September, October, November, December), and publishes clinical and basic research of all aspects of pediatrics, provided they have scientific merit and represent an important advance in knowledge. The Journal publishes original articles, review articles, case reports which provide new information, letters in relation to published articles, scientific research letters and picture of the month, announcements (meetings, courses, job advertisements); summary report of conferences and book reviews.
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