Probiotics as Functional Dietary Interventions for Gut Health, Immune Modulation, and Overall Well-Being: A Systematic Review.

IF 0.8 4区医学 Q3 PEDIATRICS

Clinical Pediatrics Pub Date : 2026-09-22 DOI:10.1177/00099228261480530

Smriti Mishra, Shikha Saxena

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引用次数: 0

Abstract

Background: The pediatric gut microbiome influences immune maturation, neurodevelopment, and disease susceptibility. Probiotic supplementation has been investigated across multiple childhood conditions, yet strain-specific efficacy remains inconsistent.

Objective: The objective of this review is to systematically evaluate strain-specific probiotic interventions in children and assess clinical efficacy, safety, and mechanistic pathways.

Methodology: A systematic review was conducted following PRISMA 2020 guidelines. PubMed, Scopus, and Web of Science were searched for studies (2006-2024).

Results: Strong evidence supports Lactobacillus rhamnosus GG and Saccharomyces boulardii for acute diarrhea. Mixed strains show moderate benefit in atopic dermatitis. Adjunct probiotic therapy improves Helicobacter pylori eradication rates. Evidence in asthma and autism spectrum disorder remains preliminary.

Conclusion: Significant heterogeneity in strains, dosing, and study design limits generalizability. Probiotic efficacy in pediatrics is strain and condition-specific. Standardized RCTs and precision microbiome approaches are required.

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益生菌作为肠道健康、免疫调节和整体健康的功能性饮食干预：系统综述。

背景：儿童肠道微生物组影响免疫成熟、神经发育和疾病易感性。益生菌补充剂已经在多种儿童条件下进行了研究，但菌株特异性功效仍然不一致。目的：本综述的目的是系统地评估菌株特异性益生菌干预儿童，评估临床疗效，安全性和机制途径。方法：按照PRISMA 2020指南进行系统评价。检索PubMed、Scopus和Web of Science的研究（2006-2024）。结果：有力的证据支持鼠李糖乳杆菌GG和博拉氏酵母治疗急性腹泻。混合菌株对特应性皮炎有中等疗效。辅助益生菌治疗提高幽门螺杆菌根除率。哮喘和自闭症谱系障碍的证据仍处于初步阶段。结论：菌株、剂量和研究设计的显著异质性限制了通用性。益生菌在儿科的功效是菌株和条件特异性的。标准化的随机对照试验和精确的微生物组方法是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Pediatrics 医学-小儿科

CiteScore

2.10

自引率

6.20%

发文量

189

审稿时长

3-8 weeks

期刊介绍： Clinical Pediatrics (CLP) a peer-reviewed monthly journal, is a must read for the busy pediatrician. CLP contains state-of-the-art, accurate, concise and down-to earth information on practical, everyday child care topics whether they are clinical, scientific, behavioral, educational, or ethical.