Neuronal Activity Rapidly Decreases the Level of p53 Protein in Rat Hippocampus In Vivo.

IF 0.7 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-21 DOI:10.1007/s10517-026-06716-8

P D Lisachev, M B Shtark

引用次数: 0

Abstract

It was previously shown that the induction of long-term post-tetanic potentiation of synaptic transmission in rat hippocampal slices is accompanied by a rapid decrease in the levels of the transcription factor p53 (tumor suppressor p53). However, it remained unclear whether a similar phenomenon could be observed in vivo. To answer this question, we employed a pentylenetetrazole (PTZ)-induced seizure model in rats. At 20 and 40 min after an intraperitoneal injection of PTZ, hippocampal p53 levels were significantly reduced compared to the intact controls. These findings validate the data previously obtained in vitro.

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神经元活动迅速降低大鼠海马p53蛋白水平。

先前的研究表明，大鼠海马切片中突触传递的长期破伤风后增强的诱导伴随着转录因子p53（肿瘤抑制因子p53）水平的快速下降。然而，目前尚不清楚是否可以在体内观察到类似的现象。为了回答这个问题，我们采用了戊四唑（PTZ）诱导的大鼠癫痫模型。在腹腔注射PTZ后20和40分钟，与未注射PTZ的对照组相比，海马p53水平显著降低。这些发现证实了先前在体外获得的数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.