Modeling Changes in Erythrocyte Volume Depending on the Conductivity of Ion Channels.

IF 0.7 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-21 DOI:10.1007/s10517-026-06719-5

T V Rudenko, A A Pecheritsyn, V P Demkin, L V Smaglii, V V Rudenko, V V Udut

引用次数: 0

Abstract

We developed a physicomathematical model for estimating transmembrane potential and cell volume responses to changes in membrane permeability to cations. Numerical simulations demonstrated that the developed model allows high-sensitivity prediction of cell volume changes depending on physiologically acceptable deviations in the permeability of passive channels for Na⁺, Ca²⁺, and K⁺ ions.

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红细胞体积随离子通道电导率的变化。

我们开发了一个物理数学模型来估计跨膜电位和细胞体积对膜对阳离子渗透性变化的反应。数值模拟表明，所开发的模型可以根据生理上可接受的Na+、Ca2+和K+离子被动通道的渗透性偏差，对细胞体积变化进行高灵敏度预测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.