Application of electrospun piezoelectric nanofibers in wound healing.

IF 11 1区医学 Q1 DERMATOLOGY

Burns & Trauma Pub Date : 2026-04-30 eCollection Date: 2026-01-01 DOI:10.1093/burnst/tkag032

Jing Wang, Jianhua Feng, Chengzhi Zhang, Xiankui Gao, Changjun Jia, Tianming Zhao, Seeram Ramakrishna, Hongye Guan

{"title":"Application of electrospun piezoelectric nanofibers in wound healing.","authors":"Jing Wang, Jianhua Feng, Chengzhi Zhang, Xiankui Gao, Changjun Jia, Tianming Zhao, Seeram Ramakrishna, Hongye Guan","doi":"10.1093/burnst/tkag032","DOIUrl":null,"url":null,"abstract":"<p><p>Wound healing is essential for maintaining organismal homeostasis and barrier function, posing significant challenges particularly in the management of hard-to-heal wounds such as diabetic ulcers. This review systematically summarizes the functional properties of piezoelectric electrospun biomaterials and their biological mechanisms in promoting wound healing via electrical stimulation (ES). Piezoelectric nanofiber wound dressings fabricated by electrospinning technology offer dual advantages: on one hand, their unique fibrous architecture enables adaptation to irregular wound contours, facilitates rapid hemostasis, and provides an effective barrier against microbial invasion; on the other hand, their inherent piezoelectric effect converts micromechanical deformations into localized electrical signals in real time, thereby modulating cellular behaviors and accelerating tissue repair. This review highlights recent studies elucidating the mechanisms by which ES promotes wound healing, and the functional characteristics of piezoelectric fibrous dressings. It aims to establish a theoretical foundation for the rational design and performance optimization of next-generation intelligent piezoelectric wound dressings, thereby advancing their clinical translation and industrial development.</p>","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"14 ","pages":"tkag032"},"PeriodicalIF":11.0000,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592679/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Burns & Trauma","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/burnst/tkag032","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Wound healing is essential for maintaining organismal homeostasis and barrier function, posing significant challenges particularly in the management of hard-to-heal wounds such as diabetic ulcers. This review systematically summarizes the functional properties of piezoelectric electrospun biomaterials and their biological mechanisms in promoting wound healing via electrical stimulation (ES). Piezoelectric nanofiber wound dressings fabricated by electrospinning technology offer dual advantages: on one hand, their unique fibrous architecture enables adaptation to irregular wound contours, facilitates rapid hemostasis, and provides an effective barrier against microbial invasion; on the other hand, their inherent piezoelectric effect converts micromechanical deformations into localized electrical signals in real time, thereby modulating cellular behaviors and accelerating tissue repair. This review highlights recent studies elucidating the mechanisms by which ES promotes wound healing, and the functional characteristics of piezoelectric fibrous dressings. It aims to establish a theoretical foundation for the rational design and performance optimization of next-generation intelligent piezoelectric wound dressings, thereby advancing their clinical translation and industrial development.

查看原文本刊更多论文

电纺压电纳米纤维在伤口愈合中的应用。

伤口愈合对于维持机体内稳态和屏障功能至关重要，这对难以愈合的伤口（如糖尿病溃疡）的治疗提出了重大挑战。本文系统综述了压电电纺生物材料的功能特性及其在电刺激下促进伤口愈合的生物学机制。采用静电纺丝技术制备的压电纳米纤维伤口敷料具有双重优势：一方面，其独特的纤维结构可以适应不规则的伤口轮廓，促进快速止血，并提供有效的微生物入侵屏障；另一方面，其固有的压电效应将微机械变形实时转化为局部电信号，从而调节细胞行为，加速组织修复。本文综述了最近的研究阐明了ES促进伤口愈合的机制，以及压电纤维敷料的功能特性。旨在为下一代智能压电创面敷料的合理设计和性能优化奠定理论基础，从而推动其临床转化和产业化发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Burns & Trauma 医学-皮肤病学

CiteScore

8.40

自引率

9.40%

发文量

186

审稿时长

6 weeks

期刊介绍： The first open access journal in the field of burns and trauma injury in the Asia-Pacific region, Burns & Trauma publishes the latest developments in basic, clinical and translational research in the field. With a special focus on prevention, clinical treatment and basic research, the journal welcomes submissions in various aspects of biomaterials, tissue engineering, stem cells, critical care, immunobiology, skin transplantation, and the prevention and regeneration of burns and trauma injuries. With an expert Editorial Board and a team of dedicated scientific editors, the journal enjoys a large readership and is supported by Southwest Hospital, which covers authors'' article processing charges.