Psychiatric comorbidities in people with and without post-traumatic epilepsy: a systematic review and meta-analysis.

IF 1.5 4区医学 Q4 NEUROSCIENCES

Brain injury Pub Date : 2026-09-21 DOI:10.1080/02699052.2026.2736707

Ali Rafati, Aditya Mittal, Churl-Su Kwon

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引用次数: 0

Abstract

Introduction: While both traumatic brain injury (TBI) and epilepsy are independently associated with psychiatric comorbidities, population-based evidence on the association between post-traumatic epilepsy (PTE) and psychiatric comorbidities is limited. We systematically reviewed psychiatric comorbidities in people with vs. without PTE.

Methods: We followed PRISMA reporting standards. Records were searched until August 2026 from MEDLINE, Embase, and PsycINFO, and were included if reported psychiatric comorbidities among people with PTE compared to control groups of i) epilepsy, ii) TBI-no-epilepsy, and/or iii) no-TBI-no-epilepsy.

Results: Of 1275 records identified, 6 were included. Sufficient data for meta-analysis was available only for depression. A pooled analysis of 2 studies on 81 people with PTE and 515 people with TBI-no-epilepsy showed no significantly different incidence proportion of depression between PTE and TBI-no-epilepsy (24/81[29.6%] vs. 121/515[23.4%]; RR:1.20 95%CI:0.83-1.74).

Conclusion: Previous evidence is sparse. We observed no significant difference in depression incidence in PTE vs. TBI-no-epilepsy. Future research should explore psychiatric comorbidities in PTE vs. TBI-no-epilepsy, epilepsy-only, and healthy controls.

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创伤后癫痫患者和非创伤后癫痫患者的精神合并症：一项系统回顾和荟萃分析。

虽然创伤性脑损伤（TBI）和癫痫都与精神合并症独立相关，但创伤后癫痫（PTE）与精神合并症之间关联的基于人群的证据有限。我们系统地回顾了pte患者与非pte患者的精神共病。方法：我们遵循PRISMA报告标准。从MEDLINE、Embase和PsycINFO检索到2026年8月的记录，并纳入与i)癫痫、ii) tbi -无癫痫和/或iii)无tbi -无癫痫对照组相比，PTE患者报告的精神合并症。结果：在1275份被识别的记录中，6份被纳入。荟萃分析的充分数据仅适用于抑郁症。对81例PTE患者和515例tbi -无癫痫患者的2项研究进行汇总分析，PTE与tbi -无癫痫患者的抑郁发生率无显著差异（24/81[29.6%]比121/515[23.4%];RR:1.20 95%CI:0.83-1.74）。结论：既往证据不足。我们观察到PTE患者与非tbi癫痫患者的抑郁发生率无显著差异。未来的研究应探讨PTE与tbi的精神合并症——非癫痫、仅癫痫和健康对照。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain injury 医学-康复医学

CiteScore

3.50

自引率

5.30%

发文量

148

审稿时长

12 months

期刊介绍： Brain Injury publishes critical information relating to research and clinical practice, adult and pediatric populations. The journal covers a full range of relevant topics relating to clinical, translational, and basic science research. Manuscripts address emergency and acute medical care, acute and post-acute rehabilitation, family and vocational issues, and long-term supports. Coverage includes assessment and interventions for functional, communication, neurological and psychological disorders.