Anthracenyl Benzimidazole: A Smart Optical Probe for Determination of Bilirubin at Nanomolar Level

IF 2.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

ChemistrySelect Pub Date : 2026-09-23 DOI:10.1002/slct.74594

Sukriti Mukherjee, Sutapa Changdar, Somnath Khanra, Sisir Lohar, Debasis Das

引用次数: 0

Abstract

A unique benzimidazole derivative viz. 2-anthracen-9-yl-1-phenyl-1H-benzoimidazole (L3) is synthesized and structurally authenticated by single crystal x-ray diffraction analysis. The L3 selectively detects bilirubin at nano molar level via ratiometric fluorescence enhancement in DMSO/H₂O (9:1, v/v) media. In presence of bilirubin the L3 forms excimer. The limit of detection (LOD) and association constant for bilirubin are 23.25 nM and 2.23×10⁵ M⁻¹ respectively. Time-correlated single photon counting (TCSPC) experiment indicates fluorescence life time enhancement from 1.84 ns for L3 to 2.46 ns, upon addition of bilirubin.

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蒽基苯并咪唑：用于纳米水平胆红素测定的智能光学探针

合成了一种独特的苯并咪唑衍生物，即2-蒽-9-基-1-苯基- 1h -苯并咪唑（L3），并通过单晶x射线衍射分析对其结构进行了验证。L3在DMSO/H2O （9:1, v/v）介质中通过比例荧光增强选择性检测纳米摩尔水平的胆红素。胆红素存在时，L3形成准分子。胆红素的检出限和关联常数分别为23.25 nM和2.23×105 M−1。时间相关单光子计数（TCSPC）实验表明，加入胆红素后，L3的荧光寿命从1.84 ns增强到2.46 ns。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemistrySelect Chemistry-General Chemistry

CiteScore

3.30

自引率

4.80%

发文量

1809

审稿时长

1.6 months

期刊介绍： ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.