Prognostic and severity value of the neutrophil-to-lymphocyte ratio in patients with acute diverticulitis: a systematic review with meta-analysis.

IF 1.8 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Scandinavian Journal of Gastroenterology Pub Date : 2026-09-21 DOI:10.1080/00365521.2026.2731965

Patricio Castro-Suárez, Alvaro Montes-Baldarrago, Jeffrey Mora-Arévalo, Miguel Cabanillas-Lazo

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引用次数: 0

Abstract

Objective: This study evaluates the neutrophil-to-lymphocyte ratio (NLR) as a potential tool for assessing acute diverticulitis (AD) severity and prognosis.

Methods: A systematic search was conducted in PubMed, Embase, Scopus, Web of Science and Google Scholar. A meta-analysis compared mean NLR values between complicated and non-complicated AD patients and those who underwent surgery versus non-surgical management.

Results: Seventeen cohort studies were included. NLR >7.2 predicted mortality (sensitivity: 80%, specificity: 60%). The optimal NLR cutoff for predicting complicated AD was 4.862, with sensitivity of 74.17% (95% CI: 56.25%; 86.51%) and specificity of 68.41% (95% CI: 52.84%; 80.71%). The mean NLR was higher in the surgical group (MD: 2.85; 95% CI: -0.24; 5.95; I2: 86%). High NLR was associated with failure of non-surgical treatment (OR: 1.65; 95% CI: 0.47; 3.90).

Conclusion: NLR may be a useful biomarker for AD severity and mortality risk. However, its relevance for predicting surgery need, treatment failure or recurrence is limited. Larger, prospective are needed to confirm its clinical utility.

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急性憩室炎患者中性粒细胞与淋巴细胞比值的预后和严重程度价值：一项荟萃分析的系统综述。

目的：本研究评估中性粒细胞与淋巴细胞比值（NLR）作为评估急性憩室炎（AD）严重程度和预后的潜在工具。方法：系统检索PubMed、Embase、Scopus、Web of Science和谷歌Scholar。一项荟萃分析比较了复杂和非复杂AD患者以及接受手术和非手术治疗的患者的平均NLR值。结果：纳入了17项队列研究。NLR bbb7.2预测死亡率（敏感性：80%，特异性：60%）。预测复杂AD的最佳NLR截止值为4.862，敏感性为74.17% (95% CI: 56.25%; 86.51%)，特异性为68.41% （95% CI: 52.84%; 80.71%）。手术组的NLR平均值更高（MD: 2.85; 95% CI: -0.24; 5.95; I2: 86%）。高NLR与非手术治疗失败相关（OR: 1.65; 95% CI: 0.47; 3.90）。结论：NLR可能是AD严重程度和死亡风险的有用生物标志物。然而，其预测手术需求、治疗失败或复发的相关性是有限的。需要更大规模的前瞻性研究来证实其临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scandinavian Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

3.40

自引率

5.30%

发文量

222

审稿时长

3-8 weeks

期刊介绍： The Scandinavian Journal of Gastroenterology is one of the most important journals for international medical research in gastroenterology and hepatology with international contributors, Editorial Board, and distribution