Hai Phuong Ly, Van Hien Nguyen, Linh Tu Vo, Thanh Triet Nguyen
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引用次数: 0
Abstract
Aims: To develop a topical cream formulation from a traditional Vietnamese herbal remedy (LXWLC) comprising Lonicera japonica, Xanthium strumarium, Wedelia chinensis, Lactuca indica, and Chromolaena odorata, and to evaluate its quality, skin irritation potential, and anti-inflammatory activity, thereby providing preliminary evidence for its potential application in inflammatory skin conditions.
Materials and methods: LXWLC cream was prepared by emulsification and evaluated according to the Vietnamese Pharmacopoeia V and ASEAN standards. Total phenolic content was determined using the Folin-Ciocalteu method. Anti-inflammatory activity was assessed by nitric oxide inhibition in RAW264.7 macrophages, skin irritation in New Zealand White rabbits, and anti-inflammatory efficacy in a croton oil-induced ear edema model in Swiss albino mice.
Results: The extract contained 226.89 ± 0.25 mg GAE/g of total phenolics and inhibited nitric oxide production (IC50 = 54.7 ± 0.2 µg/mL). The cream met quality and safety requirements and caused no skin irritation. It reduced ear thickness by 51.04%, comparable to clobetasone 0.05% (58.49%) and significantly greater than the oral extract (20.49%) (p < 0.05).
Conclusions: LXWLC cream demonstrated favorable quality, safety, and anti-inflammatory activity, supporting its potential development as a topical herbal candidate for inflammatory skin conditions.
期刊介绍：
Delivering therapeutics in a way that is right for the patient - safe, painless, reliable, targeted, efficient and cost effective - is the fundamental aim of scientists working in this area. Correspondingly, this evolving field has already yielded a diversity of delivery methods, including injectors, controlled release formulations, drug eluting implants and transdermal patches. Rapid technological advances and the desire to improve the efficacy and safety profile of existing medications by specific targeting to the site of action, combined with the drive to improve patient compliance, continue to fuel rapid research progress. Furthermore, the emergence of cell-based therapeutics and biopharmaceuticals such as proteins, peptides and nucleotides presents scientists with new and exciting challenges for the application of therapeutic delivery science and technology. Successful delivery strategies increasingly rely upon collaboration across a diversity of fields, including biology, chemistry, pharmacology, nanotechnology, physiology, materials science and engineering. Therapeutic Delivery recognizes the importance of this diverse research platform and encourages the publication of articles that reflect the highly interdisciplinary nature of the field. In a highly competitive industry, Therapeutic Delivery provides the busy researcher with a forum for the rapid publication of original research and critical reviews of all the latest relevant and significant developments, and focuses on how the technological, pharmacological, clinical and physiological aspects come together to successfully deliver modern therapeutics to patients. The journal delivers this essential information in concise, at-a-glance article formats that are readily accessible to the full spectrum of therapeutic delivery researchers.
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