Assessment of Salivary Flow Patterns in Sjögren's Disease.

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2026-09-21 DOI:10.1111/odi.70502

Mouna Alsunni, Matthew D Finkelman, Mabi Singh, Athena Papas, Vidya Sankar

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引用次数: 0

Abstract

Objective: Salivary flow may follow a circadian rhythm regulated by clock genes and aquaporins. Because aquaporin 5 dysregulation may contribute to Sjögren's disease, we investigated whether daily unstimulated and stimulated salivary flow patterns differed between participants with Sjögren's disease and healthy controls.

Methods: Thirteen participants were recruited (80% power). Participants with Sjögren's disease met the 2016 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria; healthy controls were not taking xerogenic medications. Saliva was collected at home (5:00 AM, 10:00 AM) and in the clinic (3:00 PM) for 5 min (unstimulated) and 2 min (stimulated). Differences were analysed using Friedman's test, the Mann-Whitney U test, and mixed-effects models (α = 0.05).

Results: We analysed 13 healthy controls (mean age 48.9 ± 10.7 years) and 13 participants with Sjögren's disease (mean age 65.3 ± 8.4 years). In the Sjögren's disease group, unstimulated flow did not vary over time (p = 0.463), but stimulated flow varied significantly across time points (p = 0.037). Neither measure varied significantly over time in controls (both p = 0.527).

Conclusion: Neither group showed clear evidence of a circadian salivary flow pattern, and temporal patterns did not differ significantly between groups.

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Sjögren病患者唾液流动模式的评估。

目的：唾液流动可能遵循生物钟基因和水通道蛋白调节的昼夜节律。由于水通道蛋白5失调可能导致Sjögren的疾病，我们研究了Sjögren的疾病参与者和健康对照者之间每日未受刺激和受刺激的唾液流模式是否不同。方法：招募13名参与者（80%权力率）。患有Sjögren疾病的参与者符合2016年美国风湿病学会/欧洲风湿病协会联盟的分类标准；健康对照组不服用致干药物。在家中（5:00 AM, 10:00 AM）和诊所（3:00 PM）分别采集唾液5分钟（未刺激）和2分钟（刺激）。采用Friedman检验、Mann-Whitney U检验和混合效应模型分析差异（α = 0.05）。结果：我们分析了13名健康对照者（平均年龄48.9±10.7岁）和13名Sjögren病患者（平均年龄65.3±8.4岁）。在Sjögren疾病组中，未受刺激的血流不随时间变化（p = 0.463），但受刺激的血流在不同时间点上变化显著（p = 0.037）。在对照组中，两项测量值随时间变化均不显著（p均= 0.527）。结论：两组均未显示明显的昼夜唾液流动模式，且时间模式在两组之间无显著差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.