High Serum Monounsaturated Fatty Acids Levels May Increase Risk of Cardiovascular Disease: A Mendelian Randomization Study.

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL

Iranian Journal of Medical Sciences Pub Date : 2026-08-01 DOI:10.30476/ijms.2026.107801.4239

Danial Habibi, Farshad Teymoori, Fahimeh Haghighatdoost, Sahand Tehrani Fateh, Sajedeh Masjoudi, Amir Hossein Saeidian, Alireza Soleymani Taloubaghi, Taha Rafiei, Soheil Rahmati, Mohammad Rafiei, Hossein Farhadnejad, Hanifeh Mirtavoos-Mahyari, Hakon Hakonarson, Fereidoun Azizi, Mehdi Hedayati, Maryam Sadat Daneshpour, Marjan Mansourian, Mahdi Akbarzadeh

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引用次数: 0

Abstract

Background: Monounsaturated fatty acids (MUFAs) are dietary and circulating fats that may influence cardiovascular health. However, their causal role in cardiovascular diseases (CVDs) remains unclear due to conflicting observational evidence. This study aimed to determine the causal relationship of high serum MUFAs with the risk of various CVDs using the Mendelian randomization (MR) design.

Methods: The summary statistics dataset related to serum MUFAs was used from the published genome-wide association study (GWAS) of European descent in UK Biobank participants (n=114,999). Genetic variants underlying angina, atherosclerotic, ischemic heart disease (IHD), myocardial infarction (MI), and hypertension events were ascertained using a GWAS dataset of 461,880 (case=14,828, control=447,052), 463,010 (case=12,171, control=450,839), 361,194 (case=20,857, control=340,337), 462,933 (case=10,616, control=452,317), and 461,880 (case=124,227, control=337,653) European descent participants from the UK Biobank, respectively. We investigated potential association relationships between MUFAs and these outcomes using generalized summary Mendelian randomization (GSMR) and two-sample Mendelian randomization (TSMR). TSMR was employed to validate associations identified by GSMR. The results were reported as odds ratios (ORs) with 95% confidence intervals (CIs).

Results: GSMR results showed that MUFAs were associated with angina (OR=1.007, 95%CI:1.005-1.009; P<0.001), atherosclerotic (OR=1.006, 95%CI:1.004-1.008; P<0.001), IHD (OR=1.006, 95%CI:1.003-1.009; P<0.001), MI (OR=1.003, 95%CI:1.001-1.005; P<0.001), and hypertension (OR=1.003, 95%CI:0.998-1.008; P<0.001). Besides, TSMR results indicated that MUFAs were associated with angina (OR=1.012, 95%CI:1.010-1.015), atherosclerotic (OR=1.009, 95%CI:1.006-1.011; P<0.001), IHD (OR=1.015, 95%CI:1.010-1.019; P<0.001), MI (OR=1.007, 95%CI:1.004-1.009; P<0.001), and hypertension (OR=1.021, 95%CI:1.011-1.031; P<0.001). These findings remained consistent when utilizing different MR methods and sensitivity analyses.

Conclusion: The current MR study indicated that higher levels of MUFAs might be associated with an increased risk of CVD events.Preprint Declaration: A preprint version of this manuscript is available at https://www.medrxiv.org/content/10.1101/2023.09.06.23295142v1.

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高血清单不饱和脂肪酸水平可能增加心血管疾病的风险：一项孟德尔随机研究

背景：单不饱和脂肪酸（MUFAs）是一种可能影响心血管健康的膳食脂肪和循环脂肪。然而，由于相互矛盾的观察证据，它们在心血管疾病（cvd）中的因果作用仍不清楚。本研究旨在利用孟德尔随机化（MR）设计确定高血清MUFAs与各种心血管疾病风险的因果关系。方法：与血清MUFAs相关的汇总统计数据来自已发表的英国生物银行参与者欧洲血统全基因组关联研究（GWAS）（n=114,999）。使用GWAS数据集确定心绞痛、动脉粥样硬化、缺血性心脏病（IHD）、心肌梗死（MI）和高血压事件的遗传变异，分别为461,880例（病例=14,828，对照=447,052）、463,010例（病例=12,171，对照=450,839）、361,194例（病例=20,857，对照=340,337）、462,933例（病例=10,616，对照=452,317）和461,880例（病例=124,227，对照=337,653）来自英国生物银行的欧洲血统参与者。我们使用广义总结孟德尔随机化（GSMR）和双样本孟德尔随机化（TSMR）研究了MUFAs与这些结果之间的潜在关联。采用TSMR对GSMR识别的关联进行验证。结果以95%置信区间（ci）的优势比（ORs）报告。结果：GSMR结果显示MUFAs与心绞痛相关（OR=1.007, 95%CI:1.005-1.009）结论：目前的MR研究表明，较高水平的MUFAs可能与CVD事件风险增加有关。预印本声明：此手稿的预印本版本可在https://www.medrxiv.org/content/10.1101/2023.09.06.23295142v1获得。

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来源期刊

Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

3.20

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of communication for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science research experiences on prevalent diseases in the region and analysis of various regional problems.