Limited added benefit of seasonal influenza vaccination before A(H5) vaccination in mice and ferrets challenged with A(H5N1).

IF 7 2区医学 Q1 IMMUNOLOGY

Emerging Microbes & Infections Pub Date : 2026-12-01 Epub Date: 2026-09-21 DOI:10.1080/22221751.2026.2731495

Masato Hatta, Ying Huang, Jeremy A Duke, Joseph R Rouse, Chenchen Feng, Xudong Lin, Li Wang, Melvyn R Almanzar-Jordan, Zhu-Nan Li, James Stevens, Min Z Levine, David E Wentworth, Vivien G Dugan, C Todd Davis, Bin Zhou

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Abstract

Limited A(H5)-specific vaccine supply is expected early in a potential A(H5N1) pandemic, raising the question of whether licensed seasonal influenza vaccines could enhance protection when administered before A(H5) vaccination. We evaluated this strategy in mouse and ferret models using clade 2.3.4.4b A(H5N1) viruses. Seasonal influenza vaccination induced antibodies to seasonal haemagglutinins but did not induce detectable antibodies against A(H5) and did not consistently enhance A(H5)-directed antibody responses after A(H5) vaccination. In lethal challenge studies, seasonal vaccine priming before A(H5) vaccination was associated with improved outcomes compared with A(H5) vaccination alone in one of three mouse experiments, but this effect was not observed in the other two mouse experiments or in ferrets. These findings suggest that seasonal influenza vaccine priming provides limited added benefit to A(H5) vaccine-mediated protection against A(H5N1) under the conditions tested.

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在A（H5N1）感染小鼠和雪貂中，在接种A（H5）疫苗之前接种季节性流感疫苗的额外益处有限。

在潜在的甲型（H5N1）流感大流行早期，预计会有有限的甲型（H5）特异性疫苗供应，这就提出了一个问题，即在甲型（H5）流感疫苗接种之前接种已获得许可的季节性流感疫苗是否能增强保护作用。我们使用进化支2.3.4.4b A（H5N1）病毒在小鼠和雪貂模型中评估了这一策略。季节性流感疫苗接种诱导了针对季节性血凝素的抗体，但没有诱导可检测到的针对甲型（H5）的抗体，并且在甲型（H5）疫苗接种后并没有持续增强甲型（H5）定向抗体应答。在致死性攻击研究中，在三个小鼠实验中，与单独接种A（H5）相比，在接种A（H5）疫苗之前接种季节性疫苗与改善的结果相关，但在其他两个小鼠实验或雪貂中未观察到这种效果。这些发现表明，在测试条件下，季节性流感疫苗启动对甲型H5疫苗介导的对甲型H5N1病毒的保护提供了有限的额外益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Emerging Microbes & Infections IMMUNOLOGY-MICROBIOLOGY

CiteScore

26.20

自引率

2.30%

发文量

276

审稿时长

20 weeks

期刊介绍： Emerging Microbes & Infections is a peer-reviewed, open-access journal dedicated to publishing research at the intersection of emerging immunology and microbiology viruses. The journal's mission is to share information on microbes and infections, particularly those gaining significance in both biological and clinical realms due to increased pathogenic frequency. Emerging Microbes & Infections is committed to bridging the scientific gap between developed and developing countries. This journal addresses topics of critical biological and clinical importance, including but not limited to: - Epidemic surveillance - Clinical manifestations - Diagnosis and management - Cellular and molecular pathogenesis - Innate and acquired immune responses between emerging microbes and their hosts - Drug discovery - Vaccine development research Emerging Microbes & Infections invites submissions of original research articles, review articles, letters, and commentaries, fostering a platform for the dissemination of impactful research in the field.