Recent Advances in Solvent-Free Sonogashira Coupling

IF 3.2 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - An Asian Journal Pub Date : 2026-09-20 DOI:10.1002/asia.70993

Baolei Huang, Yue Zhang, Yan Zhang, Xianqing Zhang, Caixia Xie, Hui Liu

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引用次数: 0

Abstract

The Sonogashira coupling reaction holds an irreplaceable position in fields such as drug synthesis, natural product preparation, and functional material development. Through the integration of technical means such as mechanochemistry and microwave irradiation with efficient catalytic systems, the greening and high efficiency of the Sonogashira reaction process are achieved. This paper systematically reviews the research progress of solvent-free Sonogashira coupling reactions, focusing on classifying and elaborating on the design principles, catalytic performance, and reaction mechanisms of palladium-catalyzed, copper-catalyzed, palladium-copper co-catalyzed, and other novel catalytic systems. Both standard Sonogashira (Ar-X) and acyl-Sonogashira (Ar-COCl coupling) reactions are involved. It also analyzes the advantages and limitations of each system in terms of substrate compatibility, catalytic activity, and cyclic stability, providing a reference for the theoretical research and practical application of solvent-free Sonogashira coupling reactions.

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无溶剂Sonogashira偶联的研究进展。

Sonogashira偶联反应在药物合成、天然产物制备、功能材料开发等领域具有不可替代的地位。通过机械化学、微波辐照等技术手段与高效催化体系的整合，实现了Sonogashira反应过程的绿色化、高效化。本文系统综述了无溶剂Sonogashira偶联反应的研究进展，重点对钯催化、铜催化、钯铜共催化等新型催化体系的设计原理、催化性能和反应机理进行了分类和阐述。标准Sonogashira （Ar-X）和酰基-Sonogashira （Ar-COCl偶联）反应都涉及。分析了各体系在底物相容性、催化活性、循环稳定性等方面的优势和局限性，为无溶剂Sonogashira偶联反应的理论研究和实际应用提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - An Asian Journal 化学-化学综合

CiteScore

7.00

自引率

2.40%

发文量

535

审稿时长

1.3 months

期刊介绍： Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).